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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Review Article (Mini-Review)

Recent Advances in the Application of Podophyllotoxin Derivatives to Fight Against Multidrug-Resistant Cancer Cells

Author(s): Qiuyan Guo and Enshe Jiang*

Volume 21 , Issue 19 , 2021

Published on: 13 January, 2021

Page: [1712 - 1724] Pages: 13

DOI: 10.2174/1568026621666210113163327

Price: $65


Podophyllotoxins, including epipodophyllotoxin derivatives, can act on a diverse array of drug targets in cancer cells and thus possess potent activity against various forms of cancer cell lines, including drug-resistant forms. Moreover, several podophyllotoxin derivatives represented by etoposide and teniposide, have already been approved for cancer therapy, demonstrating podophyllotoxin moiety as a useful pharmacophore for the discovery of novel anticancer agents. This review reports the recent advances in the exploitation of podophyllotoxin derivatives to fight against multidrug-resistant cancer cells. The mechanism of action and structure-activity relationship (SAR) studies are also highlighted.

Keywords: Podophyllotoxin, Epipodophyllotoxin, Anticancer, Multidrug resistance, Mechanism of action, Structure-activity relationship.

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