Chlorogenic Acid Improves PTSD-like Symptoms and Associated Mechanisms

Title:Chlorogenic Acid Improves PTSD-like Symptoms and Associated Mechanisms

Volume: 19 Issue: 12

Author(s): Xing-Dong Chen, Jun-Jie Tang, Shuang Feng, Hua Huang, Feng-Nian Lu, Xiu-Min Lu*Yong-Tang Wang*

Affiliation:

• College of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400054,China

• State Key Laboratory of Trauma, Burns and Combined Injury, Daping Hospital, Army Medical University, Chongqing 400042,China

Keywords: Chlorogenic acid, post-traumatic stress disorder, PTSD-like symptoms, learning and memory, apoptosis, oxidative stress.

Abstract: Chlorogenic acid (CGA) is a kind of traditional Chinese medicine, abundant in honeysuckle and eucommia, and has a wide range of biological activities, and pharmacological effects. Previous studies have shown that CGA can regulate learning, memory, cognitive ability, coupled with improvement to anxiety, depression, and other post-traumatic stress disorder (PTSD)-like symptoms. This article explores the protective effects of CGA on neurons through its anti-apoptotic effect, inhibition of neuroinflammation and oxidative stress, which may be the mechanisms of its improvement of PTSD-like symptoms. It may provide a new therapeutic strategy for the treatment of PTSD and its comorbidities.

Cite this article as:

Chen Xing-Dong , Tang Jun-Jie , Feng Shuang , Huang Hua , Lu Feng-Nian , Lu Xiu-Min *, Wang Yong-Tang *, Chlorogenic Acid Improves PTSD-like Symptoms and Associated Mechanisms, Current Neuropharmacology 2021; 19 (12) . https://dx.doi.org/10.2174/1570159X19666210111155110