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Coronaviruses

Editor-in-Chief

ISSN (Print): 2666-7967
ISSN (Online): 2666-7975

Letter to the Editor

Cellular Senescence and COVID-19

Author(s): Farhan Rahman Chowdhury and Tofazzal Islam*

Volume 2 , Issue 11 , 2021

Published on: 08 January, 2021

Article ID: e310821190016 Pages: 4

DOI: 10.2174/2666796701666210108120344

Abstract

Older adults are at a higher risk of developing serious illness and mortality from COVID-19. Among a multitude of factors, cellular senescence associated with ageing, obesity, cardiovascular diseases, and diabetes seems to be statistically correlated with severe SARS-CoV-2 infections and mortality. Surface proteins such as vimentin and CD26 that are differentially expressed on senescent cells seem important for SARS-CoV-2 attachment and internalization. Potential therapeutic agents against this novel virus also exhibit senolytic and anti-inflammatory actions, implicating that their beneficial effects could, in part, be attributed to their senescent cell removal and the associated inflammatory phenotype neutralizing properties. Elucidating the underlying molecular mechanisms that connect cellular senescence and severity of SARS-CoV-2 infection might help direct towards development of effective therapeutics for elderly patients of COVID-19.

Keywords: COVID-19, cellular senescence, ageing, SARS-CoV-2, COVID-19 therapeutics, senolytics.


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