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Current Microwave Chemistry


ISSN (Print): 2213-3356
ISSN (Online): 2213-3364

Letter Article

Microwave-assisted Claisen Rearrangement of 1-Allyloxy-4-hydroxybenzene in the Presence of Metal Salt

Author(s): Fumiyoshi Ozaki and Yutaka Okada*

Volume 8, Issue 1, 2021

Published on: 06 January, 2021

Page: [3 - 6] Pages: 4

DOI: 10.2174/2213335607666210106094449

open access plus


Microwave-assisted Claisen rearrangement of allyloxybenzene with a hydroxyl group was conducted in the presence of metal salts. The rearrangement was promoted in the presence of an alkali metal salt, because the reaction substrate was converted into a phenoxide-type ion, which can efficiently absorb microwaves. In contrast, a Lewis acid was strongly coordinated to the ethereal oxygen, and this structure could also absorb microwaves efficiently.

Keywords: Microwave irradiation effect, Claisen rearrangement, metal salt, allylarenes, electron density, ethereal oxygen, phenoxide ion.

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