Recent Developments in Arylation of N-Nucleophiles via Chan-Lam Reaction: Updates from 2012 Onwards

Title:Recent Developments in Arylation of N-Nucleophiles via Chan-Lam Reaction: Updates from 2012 Onwards

Volume: 19 Issue: 1

Author(s): Fahimeh Abedinifar, Mohammad Mahdavi*, Elham babazadeh Rezaei, Mehdi Asadi and Bagher Larijani

Affiliation:

• Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Keywords: Chan-Evans-Lam reaction, N-Arylation, boronic acid, cross-coupling, organic synthesis, C-N bond, catalyst.

Abstract: ''Chan-Evans-Lam'' (CEL) reaction is the copper-mediated cross-coupling of N-nucleophiles with boronic acids that was independently reported in 1998 by Chan, Evans, and Lam for the first time. This reaction is accomplished at room temperature with a remarkably wide range of nucleophiles. In the recent decade, it has been particularly attractive as a convenient method for constructing the various C– N bonds in organic synthesis. Therefore, a comprehensive survey through all reported process was crucial. In this review, we summarized research progress about N-Arylation, based on the type of N-nucleophile involved in this reaction and catalysts from 2012 onwards.

Cite this article as:

Abedinifar Fahimeh , Mahdavi Mohammad *, Rezaei babazadeh Elham , Asadi Mehdi and Larijani Bagher, Recent Developments in Arylation of N-Nucleophiles via Chan-Lam Reaction: Updates from 2012 Onwards, Current Organic Synthesis 2022; 19 (1) . https://dx.doi.org/10.2174/1570179417666210105120706