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Current Organic Chemistry


ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Review Article

A Review on Synthesis, Reactions and Biological Properties of Seven Membered Heterocyclic Compounds: Azepine, Azepane, Azepinone

Author(s): Manvinder Kaur, Sonali Garg, Dharambeer S. Malhi and Harvinder S. Sohal*

Volume 25, Issue 4, 2021

Published on: 04 January, 2021

Page: [449 - 506] Pages: 58

DOI: 10.2174/1385272825999210104222338

Price: $65


Seven membered heterocyclic Azepine and its derivatives have great pharmacological and therapeutic implications. In this review, the literature of the last fifty years has been exploited for the synthesis, reaction, and biological properties of these seven-member heterocyclic compounds. Most of the mechanisms involved the ring expansion of either five or six-membered compounds using various methods such as thermally, photo-chemically, and microwave irradiation. The systematically designed schemes involve the synthesis of different derivatives of azepine, azepinone, azepane, etc., using similar moieties by various researchers. However, there is much work yet to be done in the biological section, as it is not explored and reported in the literature; therefore, N-containing seven-membered heterocycles still have much scope for the researchers.

Keywords: Azepine, azepane, azepinone, benzazepine, dibenzazepinone, thiazipine.

Graphical Abstract
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