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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Review Article

A Therapeutic Journey of 5-Pyrazolones as a Versatile Scaffold: A Review

Author(s): Ravinder Sharma, Pooja A. Chawla*, Viney Chawla, Rajeev Verma, Nandita Nawal and Vikas Gupta

Volume 21, Issue 13, 2021

Published on: 01 January, 2021

Page: [1770 - 1795] Pages: 26

DOI: 10.2174/1389557521999210101224058

Price: $65

Abstract

A sizeable proportion of currently marketed drugs come from heterocycles. The heterocyclic moiety 5-pyrazolone is well known five-membered ring containing nitrogen. Derivatives of this wonder nucleus have exhibited activities as diverse as antimicrobial, anti-inflammatory, analgesic, antidepressant, anticonvulsant, antidiabetic, antihyperlipidemic, antiviral, antitubercular, antioxidant, anticancer and antiviral, including action against severe acute respiratory syndrome (SARS) or 3C protease inhibitor. A number of drugs based on this motif have already made it to the market. Standard texts and literature on medicinal chemistry cite different approaches for the synthesis of 5- pyrazolones. The present review provides an insight view to 5-pyrazolone synthesis, their biological profile and structure-activity relationship studies.

Keywords: Pyrazolones, anti-inflammatory, anticancer, antidepressant, antidiabetic, coronavirus, structure activity relationship.

Graphical Abstract

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