Abstract
A sizeable proportion of currently marketed drugs come from heterocycles. The heterocyclic moiety 5-pyrazolone is well known five-membered ring containing nitrogen. Derivatives of this wonder nucleus have exhibited activities as diverse as antimicrobial, anti-inflammatory, analgesic, antidepressant, anticonvulsant, antidiabetic, antihyperlipidemic, antiviral, antitubercular, antioxidant, anticancer and antiviral, including action against severe acute respiratory syndrome (SARS) or 3C protease inhibitor. A number of drugs based on this motif have already made it to the market. Standard texts and literature on medicinal chemistry cite different approaches for the synthesis of 5- pyrazolones. The present review provides an insight view to 5-pyrazolone synthesis, their biological profile and structure-activity relationship studies.
Keywords: Pyrazolones, anti-inflammatory, anticancer, antidepressant, antidiabetic, coronavirus, structure activity relationship.
Mini-Reviews in Medicinal Chemistry
Title:A Therapeutic Journey of 5-Pyrazolones as a Versatile Scaffold: A Review
Volume: 21 Issue: 13
Author(s): Ravinder Sharma, Pooja A. Chawla*, Viney Chawla, Rajeev Verma, Nandita Nawal and Vikas Gupta
Affiliation:
- Department of Pharmaceutical Chemistry and Analysis, ISF College of Pharmacy, GT Road, Moga, Punjab,India
Keywords: Pyrazolones, anti-inflammatory, anticancer, antidepressant, antidiabetic, coronavirus, structure activity relationship.
Abstract: A sizeable proportion of currently marketed drugs come from heterocycles. The heterocyclic moiety 5-pyrazolone is well known five-membered ring containing nitrogen. Derivatives of this wonder nucleus have exhibited activities as diverse as antimicrobial, anti-inflammatory, analgesic, antidepressant, anticonvulsant, antidiabetic, antihyperlipidemic, antiviral, antitubercular, antioxidant, anticancer and antiviral, including action against severe acute respiratory syndrome (SARS) or 3C protease inhibitor. A number of drugs based on this motif have already made it to the market. Standard texts and literature on medicinal chemistry cite different approaches for the synthesis of 5- pyrazolones. The present review provides an insight view to 5-pyrazolone synthesis, their biological profile and structure-activity relationship studies.
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Cite this article as:
Sharma Ravinder , Chawla A. Pooja *, Chawla Viney , Verma Rajeev , Nawal Nandita and Gupta Vikas , A Therapeutic Journey of 5-Pyrazolones as a Versatile Scaffold: A Review, Mini-Reviews in Medicinal Chemistry 2021; 21 (13) . https://dx.doi.org/10.2174/1389557521999210101224058
DOI https://dx.doi.org/10.2174/1389557521999210101224058 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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