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Current Gene Therapy


ISSN (Print): 1566-5232
ISSN (Online): 1875-5631

Review Article

Potential Non-coding RNAs from Microorganisms and their Therapeutic Use in the Treatment of Different Human Cancers

Author(s): Raju Biswas, Dipanjana Ghosh, Bhramar Dutta, Urmi Halder, Prittam Goswami and Rajib Bandopadhyay*

Volume 21 , Issue 3 , 2021

Published on: 30 December, 2020

Page: [207 - 215] Pages: 9

DOI: 10.2174/1566523220999201230204814

Price: $65


Cancer therapy describes the treatment of cancer, often with surgery, chemotherapy, and radiotherapy. Additionally, RNA interference (RNAi) is likely to be considered a new emerging, alternative therapeutic approach for silencing/targeting cancer-related genes. RNAi can exert antiproliferative and proapoptotic effects by targeting functional carcinogenic molecules or knocking down gene products of cancer-related genes. However, in contrast to conventional cancer therapies, RNAi based therapy seems to have fewer side effects. Transcription signal sequence and conserved sequence analysis-showed that microorganisms could be a potent source of non-coding RNAs. This review concluded that mapping of RNAi mechanism and RNAi based drug delivery approaches is expected to lead a better prospective of cancer therapy.

Keywords: Cancer therapy, RNA interference, carcinogenic, microorganisms, drugs delivery, RNAi based therapy.

Graphical Abstract

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