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Current Drug Discovery Technologies

Editor-in-Chief

ISSN (Print): 1570-1638
ISSN (Online): 1875-6220

Review Article

ACE2 as a Potential Target for Management of Novel Coronavirus (nCoV- 2019)

Author(s): Elham Foroozanfar, Mohamad Forouzanfar, Tahereh Farkhondeh, Saeed Samarghandian and Fatemeh Forouzanfar*

Volume 18, Issue 6, 2021

Published on: 28 December, 2020

Article ID: e130921189567 Pages: 4

DOI: 10.2174/1570163817999201228215911

Price: $65

Abstract

A novel coronavirus termed nCoV-2019 that caused an epidemic of acute respiratory syndrome in humans was first detected in Wuhan, China, in December 2019. nCoV-2019 resulted in thousands of cases of lethal disease all around the world. Unfortunately, there is no specific treatment yet, so a better understanding of the pathobiology of the disease can be helpful. The renin-angiotensin system and its products have several important physiological actions. On the other hand, this system is involved in the pathogenesis of various diseases. In this context, this review article will briefly discuss insights for understanding the role of the angiotensin-converting enzyme 2 (ACE2) receptor as a potentially attractive target for the nCoV-2019-induced acute respiratory syndrome.

Keywords: COVID-19, renin-angiotensin system, ACE2, angiotensin, SARS-like coronavirus, acute respiratory syndrome.

Graphical Abstract

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