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Mini-Reviews in Organic Chemistry


ISSN (Print): 1570-193X
ISSN (Online): 1875-6298

Mini-Review Article

The Use of Cinnamic Acid and Cinnamaldehyde, as Bio-Based Molecules, in Organic Synthesis and Preparation of Biologically Active Compounds

Author(s): Anna S. Zalivatskaya, Dmitriy N. Zakusilo and Aleksander V. Vasilyev*

Volume 18, Issue 8, 2021

Published on: 28 December, 2020

Page: [992 - 1011] Pages: 20

DOI: 10.2174/1570193X17999201228153003

Price: $65


Cinnamic acid and cinnamaldehyde may be obtained from renewable plant bio-mass, Cinnamon plants; therefore these compounds should be considered as bio-based platform chemicals for the synthesis of novel substances. This review describes recent achievements in organic synthesis based on transformations of cinnamaldehyde, cinnamic acid and its derivatives, focusing, mainly, on the preparation of biologically active compounds. Reactions of these cinnamic derivatives may proceed both onto carbon-carbon double bond and carbonyl group that allows obtaining a wide variety of organic compounds having high synthetic importance and different practically valuable properties, including biological activity.

Keywords: Cinnamic acid, cinnamaldehyde, organic synthesis, biologically active compounds, drugs, renewable plant resources.

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