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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Resveratrol and Prostate Cancer: The Power of Phytochemicals

Author(s): Nadia Zaffaroni and Giovanni L. Beretta*

Volume 28 , Issue 24 , 2021

Published on: 28 December, 2020

Page: [4845 - 4862] Pages: 18

DOI: 10.2174/0929867328666201228124038

Price: $65

Abstract

Prostate cancer is the fifth cause of tumor-related deaths in man worldwide. Due to its long latency period, this pathology represents an ideal type of disease for chemopreventive studies. Among the drugs considered thus far for the treatment of prostate cancer, the natural compound resveratrol emerged as very promising. Resveratrol is widely recognized as a chemopreventive agent and was shown to potentiate the antitumor activity of conventional chemotherapeutics in several tumors, including prostate cancer. Here, we overview the literature of the last five years and summarize the recent achievements of resveratrol and its derivatives as antimetastatic agents in prostate cancer. Moreover, drug combination studies as well as nanomedicine approaches proposed to improve resveratrol activity and to overcome delivery drawbacks are addressed. The last part of the review discusses the clinical trials containing resveratrol ongoing on cancer patients.

Keywords: Prostate cancer, resveratrol, stilbenoids, metastasis, clinical trials, drug combination.


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