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Current Radiopharmaceuticals

Editor-in-Chief

ISSN (Print): 1874-4710
ISSN (Online): 1874-4729

Review Article

A Review of Accelerator-Produced Ga-68 with Solid Targets

Author(s): Kaelyn V. Becker, Margarita Chernysheva, Todd E. Barnhart, Katherine Gagnon and Jonathan W. Engle*

Volume 14, Issue 4, 2021

Published on: 24 December, 2020

Page: [315 - 324] Pages: 10

DOI: 10.2174/1874471013666201224113651

Price: $65

Abstract

Gallium-68 is a positron-emitting nuclide that has recently achieved clinical acceptance as the diagnostic radionuclide in PET tracers used for theranostic studies of lutetium-177 labeled therapeutic drugs due to the ease of access provided by germanium-68/gallium-68 generators. An alternative method of production currently being explored uses accelerators to form gallium-68 directly. This review of gallium-68 production strategies discusses available accelerator targetry at a range of beam energies and intensities, the many radiochemical separation techniques available to isolate Ga-68 from irradiated targets, isotopically enriched target material recovery, and the implications of these techniques for downstream radiolabeling applications.

Keywords: Radiochemical, PET, therapeutic molecule, gallium-68, radiochemistry, Lu-177 labeled.

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