Abstract
Background: Nanosuspensions are colloidal systems consisting of pure drug and stabilizers, without matrix or lyophilized into a solid matrix. Nanosuspensions improve the solubility of the drug both in the aqueous and organic phases. Nanosuspensions are also known as brick dust molecules, as they increase the dissolution of a system and improve absorption.
Methods: Extensive information related to nanosuspensions and its associated patents were collected using Pub Med and Google Scholar.
Results: Over the last decade nanosuspensions have attracted tremendous interest in pharmaceutical research. It provides unique features including, improved solubility, high drug loading capacity, and passive targeting. These particles are cost-effective, simple, and have lesser side effects with minimal dose requirements. However, the stability of nanosuspensions still warrants attention.
Conclusion: Nanosuspensions play a vital role in handling the numerous drug entities with difficult physico-chemical characteristics such as solubility and can further aid with a range of routes that include nasal, transdermal, ocular, parenteral, pulmonary etc. This review highlights the relevance of nanosuspensions in achieving safe, effective and targeted drug delivery.
Keywords: Nanosuspension, colloidal, stability, spin coating, high-pressure homogenization, dissolution rate.
Recent Patents on Nanotechnology
Title:Nanosuspensions - An Update on Recent Patents, Methods of Preparation, and Evaluation Parameters
Volume: 15 Issue: 4
Author(s): Harpreet K. Khanuja, Rajendra Awasthi, Meenu Mehta, Saurabh Satija, Alaa A.A. Aljabali, Murtaza M. Tambuwala, Dinesh K. Chellappan, Kamal Dua and Harish Dureja*
Affiliation:
- Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak,India
Keywords: Nanosuspension, colloidal, stability, spin coating, high-pressure homogenization, dissolution rate.
Abstract:
Background: Nanosuspensions are colloidal systems consisting of pure drug and stabilizers, without matrix or lyophilized into a solid matrix. Nanosuspensions improve the solubility of the drug both in the aqueous and organic phases. Nanosuspensions are also known as brick dust molecules, as they increase the dissolution of a system and improve absorption.
Methods: Extensive information related to nanosuspensions and its associated patents were collected using Pub Med and Google Scholar.
Results: Over the last decade nanosuspensions have attracted tremendous interest in pharmaceutical research. It provides unique features including, improved solubility, high drug loading capacity, and passive targeting. These particles are cost-effective, simple, and have lesser side effects with minimal dose requirements. However, the stability of nanosuspensions still warrants attention.
Conclusion: Nanosuspensions play a vital role in handling the numerous drug entities with difficult physico-chemical characteristics such as solubility and can further aid with a range of routes that include nasal, transdermal, ocular, parenteral, pulmonary etc. This review highlights the relevance of nanosuspensions in achieving safe, effective and targeted drug delivery.
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Cite this article as:
Khanuja K. Harpreet , Awasthi Rajendra, Mehta Meenu, Satija Saurabh , Aljabali A.A. Alaa , Tambuwala M. Murtaza, Chellappan K. Dinesh , Dua Kamal and Dureja Harish *, Nanosuspensions - An Update on Recent Patents, Methods of Preparation, and Evaluation Parameters, Recent Patents on Nanotechnology 2021; 15 (4) . https://dx.doi.org/10.2174/1872210514666201224103010
DOI https://dx.doi.org/10.2174/1872210514666201224103010 |
Print ISSN 1872-2105 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-4020 |
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