Generic placeholder image

Current Medical Imaging


ISSN (Print): 1573-4056
ISSN (Online): 1875-6603

Review Article

Significance of MRI Guided Focused Ultrasound Thalamotomy for Parkinson’s Disease: A Review

Author(s): N.A. Pooja, S.K. Pahuja and K. Veer*

Volume 17, Issue 6, 2021

Published on: 23 December, 2020

Page: [714 - 719] Pages: 6

DOI: 10.2174/1573405616666201223142505

Price: $65


Background: Magnetic-Resonance guided Focused Ultrasound (FUS) thalamotomy is a new and less invasive surgical technique for treating Parkinson’s disease (PD). During therapy, the required part of the cerebral (as STN, Internal Globus Pallidus, and Ventral Intermediate Nucleus) is ablated with less possibility of infection and brain hemorrhage as it normally happens in invasive procedures.

Introduction: New advancement in the technique enables it for transcranial transportation of US. Nowadays, US coupling with MRI confirms the accurate energy transferring and monitoring. So, MRI guided FUS lesioning is discovered for various psychiatric and brain disorders.

Methods: A technical overview of non-invasive MRI-FUS thalamotomy to treat various tremors is described here. Research, review articles, and book chapters are extracted from online resources using related search strings from the year 1994-2020.

Results: MRgFUS is concluded a non-invasive, satisfactory, and safe technique to reduce the tremor.

Conlusion: MRgFUS is comparatively a new method that is being explored as a non-invasive cerebral ablation to solve the problems of movement disorder.

Keywords: Stereotactic surgery, focused ultrasound, magnetic resonance imaging, tremor, thalamotomy, parkinson's disease.

Graphical Abstract
Schlesinger I, Sinai A, Zaaroor M. MRI-Guided focused ultrasound in parkinson’s disease: A review. parkinsons dis 2017; 2017: 8124624.
[] [PMID: 28465861]
Magara A, Bühler R, Moser D, Kowalski M, Pourtehrani P, Jeanmonod D. First experience with MR-guided focused ultrasound in the treatment of Parkinson’s disease. J Ther Ultrasound 2014; 2: 11.
[] [PMID: 25512869]
Moosa S, Martínez-Fernández R, Elias WJ, Del Alamo M, Eisenberg HM, Fishman PS. The role of high-intensity focused ultrasound as a symptomatic treatment for Parkinson’s disease. Mov Disord 2019; 34(9): 1243-51.
[] [PMID: 31291491]
Louis ED. Treatment of essential tremor: Are there issues we are overlooking? Front Neurol 2012; 2(91): 91.
[PMID: 22275907]
Bain PG, Findley LJ, Thompson PD, et al. A study of hereditary essential tremor. Brain 1994; 117(Pt 4): 805-24.
[] [PMID: 7922467]
Zesiewicz TA, Elble RJ, Louis ED, et al. Evidence-based guideline update: treatment of essential tremor: report of the Quality Standards subcommittee of the American Academy of Neurology. Neurology 2011; 77(19): 1752-5.
[] [PMID: 22013182]
Rajput A, Robinson CA, Rajput AH. Essential tremor course and disability: A clinicopathologic study of 20 cases. Neurology 2004; 62(6): 932-6.
[] [PMID: 15037695]
Benito-León J, Louis ED. Management of essential tremor, including medical and surgical approaches. Handb Clin Neurol 2011; 100: 449-56.
[] [PMID: 21496601]
Børretzen MN, Bjerknes S, Sæhle T, et al. Long-term follow-up of thalamic deep brain stimulation for essential tremor - patient satisfaction and mortality. BMC Neurol 2014; 14: 120.
[] [PMID: 24903550]
Hamani C, Lozano AM. Hardware-related complications of deep brain stimulation: a review of the published literature. Stereotact Funct Neurosurg 2006; 84(5-6): 248-51.
[] [PMID: 17063047]
Hamani C, Richter E, Schwalb JM, Lozano AM. Bilateral subthalamic nucleus stimulation for Parkinson’s disease: a systematic review of the clinical literature. Neurosurgery 2005; 56(6): 1313-21.
[] [PMID: 15918948]
Ohye C, Higuchi Y, Shibazaki T, et al. Gamma knife thalamotomy for Parkinson disease and essential tremor: a prospective multicenter study. Neurosurgery 2012; 70(3): 526-35.
[] [PMID: 21904267]
Young RF, Li F, Vermeulen S, Meier R. Gamma Knife thalamotomy for treatment of essential tremor: long-term results. J Neurosurg 2010; 112(6): 1311-7.
[] [PMID: 19895197]
Lim SY, Hodaie M, Fallis M, Poon YY, Mazzella F, Moro E. Gamma knife thalamotomy for disabling tremor: a blinded evaluation. Arch Neurol 2010; 67(5): 584-8.
[] [PMID: 20457958]
Hesley GK, Gorny KR, Henrichsen TL, Woodrum DA, Brown DL. A clinical review of focused ultrasound ablation with magnetic resonance guidance: an option for treating uterine fibroids. Ultrasound Q 2008; 24(2): 131-9.
[] [PMID: 18528271]
Liberman B, Gianfelice D, Inbar Y, et al. Pain palliation in patients with bone metastases using MR-guided focused ultrasound surgery: a multicenter study. Ann Surg Oncol 2009; 16(1): 140-6.
[] [PMID: 19002530]
McDannold N, Clement GT, Black P, Jolesz F, Hynynen K. Transcranial magnetic resonance imaging- guided focused ultrasound surgery of brain tumors: initial findings in 3 patients. Neurosurgery 2010; 66(2): 323-32.
[] [PMID: 20087132]
Martin E, Jeanmonod D, Morel A, Zadicario E, Werner B. High-intensity focused ultrasound for noninvasive functional neurosurgery. Ann Neurol 2009; 66(6): 858-61.
[] [PMID: 20033983]
Monteith S, Sheehan J, Medel R, et al. Potential intracranial applications of magnetic resonance-guided focused ultrasound surgery. J Neurosurg 2013; 118(2): 215-21.
[] [PMID: 23176339]
Chang WS, Jung HH, Kweon EJ, Zadicario E, Rachmilevitch I, Chang JW. Unilateral magnetic resonance guided focused ultrasound thalamotomy for essential tremor: practices and clinicoradiological outcomes. J Neurol Neurosurg Psychiatry 2015; 86(3): 257-64.
[] [PMID: 24876191]
Sinai A, Katz Y, Zaaroor M, Sandler O, Schlesinger I. The Role of the Anesthesiologist during magnetic resonance-guided focused ultrasound thalamotomy for tremor: A single-center experience. Parkinsons Dis 2018.
Chang WS, Jung HH, Zadicario E, et al. Factors associated with successful magnetic resonance-guided focused ultrasound treatment: efficiency of acoustic energy delivery through the skull. J Neurosurg 2016; 124(2): 411-6.
[] [PMID: 26361280]
Minati L, Grisoli M, Carella F, De Simone T, Bruzzone MG, Savoiardo M. Imaging degeneration of the substantia nigra in Parkinson disease with inversion-recovery MR imaging. AJNR Am J Neuroradiol 2007; 28(2): 309-13.
[PMID: 17297002]
Kwon DH, Kim JM, Oh SH, et al. Seven-Tesla magnetic resonance images of the substantia nigra in Parkinson disease. Ann Neurol 2012; 71(2): 267-77.
[] [PMID: 22367998]
Saeed U, Compagnone J, Aviv RI, et al. Imaging biomarkers in Parkinson’s disease and Parkinsonian syndromes: current and emerging concepts. Transl Neurodegener 2017; 6: 8.
[] [PMID: 28360997]
Violeta MLM-GVMITNG. Clinical and computed tomography studies of parkinson's disease. Int J Sci Res (Ahmedabad) 2015; 4: 1463-7.
Lipsman N, Schwartz ML, Huang Y, et al. MR-guided focused ultrasound thalamotomy for essential tremor: a proof-of-concept study. Lancet Neurol 2013; 12(5): 462-8.
[] [PMID: 23523144]
Elias WJ, Huss D, Voss T, et al. A pilot study of focused ultrasound thalamotomy for essential tremor. N Engl J Med 2013; 369(7): 640-8.
[] [PMID: 23944301]
Elias WJ, Lipsman N, Ondo WG, et al. A randomized trial of focused ultrasound thalamotomy for essential tremor. N Engl J Med 2016; 375(8): 730-9.
[] [PMID: 27557301]
Martínez-Fernández R, Rodríguez-Rojas R, Del Álamo M, et al. Focused ultrasound subthalamotomy in patients with asymmetric Parkinson’s disease: a pilot study. Lancet Neurol 2018; 17(1): 54-63.
[] [PMID: 29203153]
Programme IP. National Institute for Health and Care Excellence (NICE). Grants Regist 2019.
Rodriguez-Rojas R, Pineda-Pardo JA, Martinez-Fernandez R, et al. Functional impact of subthalamotomy by magnetic resonance-guided focused ultrasound in Parkinson’s disease: a hybrid PET/MR study of resting-state brain metabolism. Eur J Nucl Med Mol Imaging 2020; 47(2): 425-36.
[] [PMID: 31705173]
Wang TR, Bond AE, Dallapiazza RF, et al. Transcranial magnetic resonance imaging-guided focused ultrasound thalamotomy for tremor: technical note. Neurosurg Focus 2018; 44(2): E3.
[] [PMID: 29385914]
Harnof S, Zibly Z, Cohen Z, Shaw A, Schlaff C, Kassel NF. Cranial nerve threshold for thermal injury induced by MRI-guided high-intensity focused ultrasound (MRgHIFU): preliminary results on an optic nerve model. IEEE Trans Ultrason Ferroelectr Freq Control 2013; 60(4): 702-5.
[] [PMID: 23549530]
Kullervo H, Natalia V. H. Chung Andrew, Sorrentino Vincenza, Colucci Vincent, Jolesz Ferenc. Thermal Effects of Focused Ultrasound on the Brain: Determination Ultrasound with MR Imaging. Radiology 1997; 247-53.
Jung HH, Kim SJ, Roh D, et al. Bilateral thermal capsulotomy with MR-guided focused ultrasound for patients with treatment-refractory obsessive-compulsive disorder: a proof-of-concept study. Mol Psychiatry 2015; 20(10): 1205-11.
[] [PMID: 25421403]
Peters RD, Hinks RS, Henkelman RM. Heat-source orientation and geometry dependence in proton-resonance frequency shift magnetic resonance thermometry. Magn Reson Med 1999; 41(5): 909-18.
[<909::AID-MRM9>3.0.CO;2-N] [PMID: 10332873]
Sinai A, Nassar M, Eran A, et al. Magnetic resonance-guided focused ultrasound thalamotomy for essential tremor: a 5-year single-center experience. J Neurosurg 2019; 1-8.
[PMID: 31277064]
Connor CW, Hynynen K. Patterns of thermal deposition in the skull during transcranial focused ultrasound surgery. IEEE Trans Biomed Eng 2004; 51(10): 1693-706.
[] [PMID: 15490817]

Rights & Permissions Print Export Cite as
© 2022 Bentham Science Publishers | Privacy Policy