Advances in Stem Cell Therapy for Brain Diseases via the Intranasal Route

Title:Advances in Stem Cell Therapy for Brain Diseases via the Intranasal Route

Volume: 22 Issue: 11

Author(s): Preeti Dali and Pravin Shende*

Affiliation:

• Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM’s NMIMS, V.L. Mehta Road, Vile Parle (W), Mumbai,India

Keywords: Intranasal delivery, stem cells, blood-brain barrier, brain targeting, nanotechnology, neurological disorders.

Abstract: Stem cell therapy efficiently targets the brain for most neurological disorders like migraine, Parkinsonism, schizophrenia, Alzheimer’s disease, and brain injury. The major obstacles in potential brain targeting are the physiological barriers like blood-brain-barrier and bloodcerebrospinal fluid barrier. The conventional injectable route or direct transplantation of stem cells results in brain injury and is less feasible clinically. The alternative to these invasive routes is the intranasal route that is non-invasive, easily repeatable technique and highly effective in brain targeting without crossing the blood-brain barrier. Extensive research has been undertaken for the delivery of stem cells to the brain via the intranasal route that holds great potential in overcoming the existing barriers. Nanotechnology is emerging as a novel interdisciplinary field in the arena of stem cell research. The combination of nanotechnology coupled with stem cell therapy has led to synergistic outcomes in diagnostic and therapeutic applications of neurological diseases. This review provides insights into stem cell-based nanotherapy for brain targeting via the intranasal route.

Cite this article as:

Dali Preeti and Shende Pravin *, Advances in Stem Cell Therapy for Brain Diseases via the Intranasal Route, Current Pharmaceutical Biotechnology 2021; 22 (11) . https://dx.doi.org/10.2174/1389201021666201218130947