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Combinatorial Chemistry & High Throughput Screening

Editor-in-Chief

ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

Review Article

Envisioning the Future of Nanomedicines in Management and Treatment of Neurological Disorders

Author(s): Shobhit Kumar*, Priyanka Singh, Shrestha Sharma, Faheem H. Pottoo, Javed Ali and Sanjula Baboota

Volume 24 , Issue 10 , 2021

Published on: 17 December, 2020

Page: [1544 - 1556] Pages: 13

DOI: 10.2174/1386207323666201217151132

Price: $65

Abstract

Neurodegenerative disorders are a result of continuous deterioration of the structure and function of neurons, involving the death of neurons. Neurodegenerative disorders affect millions of people around the world. Several conventional drug delivery strategies are available to treat neurological disorders. However, they are unable to provide adequate cytoarchitecture restoration and connection patterns due to lower solubility, poor bioavailability, drug resistance and incapability to traverse the blood-brain barrier (BBB). Therefore, designing and developing new and efficient delivery systems, that can bring drugs to CNS and have good bioavailability in the brain is very important. Nano drug delivery system acts as a ray of hope in the diagnosis and treatment of neurological disorders. The use of nanomedicines encapsulating therapeutic molecules may enhance transport of drug across BBB, absorption of drug and its controlled release in the human body with minimum adverse effects. This review article includes a comprehensive overview of the BBB, recent developments and application of nanomedicines, including liposomes, nanoparticles, nanomicelles, carbon nanotubes, etc., to the management as well as clinical therapy of various neurodegenerative disorders.

Keywords: Nanomedicines, neurological disorder, nanoparticles, nanocrystals, neurodegenerative disorders, central nervous system.


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