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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

A Comparative Analysis of Different Enzyme Immobilization Nanomaterials: Progress, Constraints and Recent Trends

Author(s): Fatemeh Borzouee, Jaleh Varshosaz*, Reza Ahangari Cohan, Dariush Norouzian and Razieh Taghizadeh Pirposhteh

Volume 28 , Issue 20 , 2021

Published on: 14 December, 2020

Page: [3980 - 4003] Pages: 24

DOI: 10.2174/0929867328999201214225249

Price: $65


Immobilization techniques have been popularly used to preserve the operational stability of the enzymes for industrial applications. The three main components of an immobilized enzyme system are the enzyme, the matrix/support, and the technique of immobilization. So far, different supports have been developed to improve the efficiency of the immobilized enzymes. But in the recent decade, nanotechnology has been of considerable research interest in the field of immobilized enzyme carriers. The materials at the nano-scale, due to their unique physicochemical properties, including; specific surface area, mass transfer limitation, and effective enzyme loading, are considered interesting matrices for enzyme immobilization. This review describes techniques employed to immobilize enzymes, and provides an integrated focus on the most common nanoparticles for enzyme conjugation. Additionally, the pros and cons of nanoparticles as immobilization matrices are also discussed. Depending on the type of enzyme and its application, in this review, the researchers are directed to select an appropriate method and support for enzyme immobilization in terms of enzyme stability and functionality.

Keywords: Enzyme immobilization methods, nanomaterials, enzyme Stability, biosensor, industrial applications, matrix.

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