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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Review Article

Medicinal and Biological Significance of Phenoxazine Derivatives

Author(s): Shruti Shukla*, Jaya Dwivedi, Neetu Yaduvanshi and Sonika Jain

Volume 21 , Issue 12 , 2021

Published on: 14 December, 2020

Page: [1541 - 1555] Pages: 15

DOI: 10.2174/1389557520666201214102151

Price: $65

Abstract

Since 1887, phenoxazine derivatives have attracted the attention of chemists due to their versatile utility, industrially and pharmacologically. Literature is found abundant with various pharmacological activities of phenoxazine derivatives like antitumor, anticancer, antifungal, antibacterial, anti-inflammatory, anti-diabetic, anti-viral, anti-malarial, anti-depressant, analgesic and many other drug resistance reversal activities. This review covers a detailed overview of the pharmacological application of phenoxazine nucleus, its chemistry and reactivity, and also illustrating the incorporation of different groups at different positions enhancing its biological application, besides some synthetic procedures.

Keywords: Phenoxazine derivatives, pharmacological activity, biological significance, anticancer, antitumor, reactivity, synthesis.

Graphical Abstract

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