Effect of Antihypertensive Drugs on Cognition and Behavioral Symptoms of Patients with Alzheimer’s Disease: A Meta-analysis

Title:Effect of Antihypertensive Drugs on Cognition and Behavioral Symptoms of Patients with Alzheimer’s Disease: A Meta-analysis

Volume: 22 Issue: 11

Author(s): Roja Rahimi, Shekoufeh Nikfar, Masoud Sadeghi, Mohammad Abdollahi, Reza H. Moghaddam and Mohammad H. Farzaei*

Affiliation:

• Medical Technology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah,Iran

Keywords: Alzheimer, hypertension, meta-analysis, antihypertensive drugs, cognition, behavioral symptoms.

Abstract:

Background: It has been found that there is a link between hypertension and elevated risk of Alzheimer’s Disease (AD). Herein, a meta-analysis based on Randomized Clinical Trials (RCTs) was used to assess the effect of antihypertensive drugs on cognition and behavioral symptoms of AD patients.

Methods: The three databases, PubMed/Medline, Scopus, and Cochrane Library, were searched up to March 2020. The quality of the studies included in the meta-analysis was evaluated by the Jadad score. Clinical Global Impression of Change (CGIC) included in two studies, Mini-Mental State Examination (MMSE) included in three studies, and Neuropsychiatric Inventory (NPI) in three studies were the main outcomes in this systematic review.

Results: Out of 1506 studies retrieved in the databases, 5 RCTs were included and analyzed in the meta-analysis. The pooled mean differences of CGIC, MMSE, and NPI in patients with AD receiving antihypertensive drugs compared to placebo were -1.76 with (95% CI = -2.66 to -0.86; P=0.0001), 0.74 (95% CI = 0.20 to 1.28; P= 0.007), and -9.49 (95% CI = -19.76 to 0.79; P = 0.07), respectively.

Conclusion: The findings of the present meta-analysis show that antihypertensive drugs may improve cognition and behavioral symptoms of patients with AD. However, more well-designed RCTs with similar drugs are needed to achieve more conclusive results.

Cite this article as:

Rahimi Roja, Nikfar Shekoufeh , Sadeghi Masoud, Abdollahi Mohammad , Moghaddam H. Reza and Farzaei H. Mohammad *, Effect of Antihypertensive Drugs on Cognition and Behavioral Symptoms of Patients with Alzheimer’s Disease: A Meta-analysis, Current Pharmaceutical Biotechnology 2021; 22 (11) . https://dx.doi.org/10.2174/1386207323666201211101720