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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Review Article

Imidazole Derivatives and their Antibacterial Activity - A Mini-Review

Author(s): Gâz Șerban Andrei*, Boda Francisc Andrei* and Pop Rahela Roxana

Volume 21, Issue 11, 2021

Published on: 09 December, 2020

Page: [1380 - 1392] Pages: 13

DOI: 10.2174/1389557520999201209213648

Price: $65


Background: The development of drug resistance by bacterial strains is a public health issue, being the main cause of the decrease in the effectiveness of numerous antibiotics. In this context, it is essential to find new drugs with better antibacterial activity.

Objective: The authors proposed to cover relevant literature, published following the review article written by Rani et al., illustrating chemical structures and antibacterial activity of some imidazole derivatives.

Method: Approximately 100 scientific articles presenting more than 150 compounds have been reviewed. The most relevant data have been extracted and systematically arranged in figures and tables.

Results: The reviewed studies used a broad number of bacterial strains, however Staphylococcus aureus as Gram-positive, and Escherichia coli as Gram-negative bacterial strains were most frequently used to assess the activity of these compounds.

Conclusion: Some of the compounds showed promising results against both Gram-positive and Gram-negative bacterial strains, thus further analysis should be performed in terms of toxicity, pharmacokinetics and pharmacodynamics. Additional screening of these imidazole derivatives could lead to useful compounds with potential broad-spectrum antibacterial activity against resistant pathogens.

Keywords: Imidazole, Benzimidazole, Antibacterial Activity, Inhibitory Concentration, Structure Activity Relationship, Antibacterial Drug, Staphylococcus aureus, Escherichia coli

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