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CNS & Neurological Disorders - Drug Targets

Editor-in-Chief

ISSN (Print): 1871-5273
ISSN (Online): 1996-3181

Review Article

Autophagic Dysfunction in Dementia: Scope for Development of Potential Remedies

Author(s): Bhumika Kumar, Mukesh Pandey, Ashwini Kumar Mishra, Anjali Sharma, Faizana Fayaz and Faheem Hyder Pottoo*

Volume 20 , Issue 8 , 2021

Published on: 08 December, 2020

Page: [704 - 722] Pages: 19

DOI: 10.2174/1871527319666201209112256

Price: $65

Abstract

Dementia is a diverse category of chronic and progressive disorder, which is commonly associated with a loss of memory, difficulty in judgment, impaired language, cognitive impairment, and various other symptoms that affect a person’s daily routine life and social life. Dementia affects about 50 million people around the globe. Dementia exists in varied forms and is associated with various neurodegenerative disorders. Alzheimer's disease is the most common form, which accords for about 60% of thecases. Abnormal agglomeration of proteins in the brain has been linked to the pathogenesis of dementia. Autophagy is a necessary protein clearance mechanism, which is dependent on lysosomes. It is a basic physiological process that performs the crucial function of maintaining protein homeostasis within the cells. The autophagic dysfunction in dementia further complicates the disease by hampering the degradation and removing abnormal pathogenic proteins. In order to understand autophagic dysfunction, it is essential to know the genetics of autophagy as well as the mutations This understanding at the genetic level helps definethe relationship between dementia and autophagic dysfunction for developing the potential remedies for the treatment of dementia.

Keywords: Dementia, autophagy, autophagy dysfunction, neurodegenerative disorders, protein haemostasis, Autophagy Proteins (ATGs).

Graphical Abstract

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