Generic placeholder image

Current Protein & Peptide Science


ISSN (Print): 1389-2037
ISSN (Online): 1875-5550

Review Article

Understanding The Role of Inflammasome in Angina Pectoris

Author(s): Ishita Sharma, Tapan Behl*, Simona Bungau, Monika Sachdeva, Arun Kumar, Gokhan Zengin and Sandeep Arora

Volume 22, Issue 3, 2021

Published on: 08 December, 2020

Page: [228 - 236] Pages: 9

DOI: 10.2174/1389203721999201208200242

Price: $65


Angina pectoris, associated with coronary artery disease, a cardiovascular disease where the pain is caused by adverse oxygen supply in the myocardium, results in contractility and discomfort in the chest. Inflammasomes, triggered by stimuli due to infection and cellular stress, have been identified to play a vital role in the progression of cardiovascular disorders and, thus, causing various symptoms like angina pectoris. Nlrp3 inflammasome, a key contributor in the pathogenesis of angina pectoris, requires activation and primary signaling for the commencement of inflammation. Nlrp3 inflammasome elicits out an inflammatory response by the emission of pro-inflammatory cytokines by ROS (reactive oxygen species) production, mobilization of K+ efflux and Ca2+ and by activation of lysosome destabilization that eventually causes pyroptosis, a programmed cell death process. Thus, inflammasome is considered to be one of the factors involved in the progression of coronary artery diseases and has an intricate role in the development of angina pectoris.

Keywords: Angina pectoris, inflammasomes, Nlrp3 inflammasome, coronary artery disease, pyroptosis, cardiovascular disease.

Graphical Abstract

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy