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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Targeting the JAK/STAT Signaling Pathway for Breast Cancer

Author(s): Fei Shao, Xiaonan Pang and Gyeong Hun Baeg*

Volume 28 , Issue 25 , 2021

Published on: 07 December, 2020

Page: [5137 - 5151] Pages: 15

DOI: 10.2174/0929867328666201207202012

Price: $65

Abstract

Breast cancer is the most common malignant tumor in women worldwide. Traditional ways of treatment, including radiotherapy and endocrine therapy, for breast cancer have inevitable side effects. In recent decades, targeted therapies for breast cancer have rapidly advanced and shown a promising future. The JAK/STAT signaling pathway has been shown to play important roles in tumorigenesis, maintenance and metastasis of breast cancer. Hence, many small molecule inhibitors of JAK and STAT proteins have been developed. These inhibitors exhibit potent inhibitory effects on breast cancer in both cellular and animal models, and even some of them have already been in clinical trials. This review article discussed the JAK/STAT signal transduction pathway in the pathogenesis of breast cancer, and the potential for the application of JAK/STAT inhibitors in breast cancer treatment.

Keywords: Breast cancer, JAK/STAT pathway, inhibitors, targeted therapy, therapeutics, STAT3 dimerization.


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