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当代肿瘤药物靶点

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Research Article

SARS-CoV-2 人类靶标在肿瘤和非肿瘤肺组织中的表达和临床意义

卷 21, 期 5, 2021

发表于: 07 December, 2020

页: [428 - 442] 页: 15

弟呕挨: 10.2174/1568009620666201207145019

价格: $65

摘要

背景：包括肺癌患者在内的癌症患者的 COVID-19 感染发生率较高。进行这项研究是为了深入了解癌症中 COVID-19 感染频率的增加。 方法：使用不同的生物信息学工具，分析健康和恶性组织中 ACE2 和 TMPRSS2 的表达和甲基化模式，重点关注肺腺癌，并将数据与临床参数和吸烟史相关联。 结果：ACE2 和 TMPRSS2 在 36 个健康组织中异质表达，消化、泌尿和生殖器官中表达水平最高，而对 72 个配对组织的整体分析表明，与正常对应物相比，癌组织中 ACE2 的表达水平显着降低。相比之下，ACE2 而非 TMPRSS2 在 LUAD 中过表达，这与启动子甲基化呈负相关。 ACE2 的这种上调在 LUAD 中具有年龄依赖性，但在正常肺组织中则不然。 TMPRSS2 在非肿瘤肺组织中的表达是异质的，取决于性别和吸烟史，而在吸烟者的 LUAD 中表达下调。癌症进展与降低的 TMPRSS2 但未改变的 ACE2 相关。相比之下，来自不同癌症亚型的肺转移瘤的ACE2和TMPRSS2高于其他部位的器官转移瘤。 TMPRSS2 与 LUAD 患者的生存相关，但与 ACE2 无关。 结论：综合分子分析揭示了 ACE2 和 TMPRSS2 在健康肺与 LUAD 组织中不同性别、年龄和吸烟史的异质性和独特的表达和/或甲基化特征，可能对 COVID-19 疾病有影响。

关键词: COVID-19，转移，肺腺癌，ACE2，TMPRSS2，临床相关性。

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