摘要
2019冠状病毒病(COVID-19)是当前威胁世界的一场新的公众健康危机。这种大流行疾病是由严重急性呼吸综合征冠状病毒2 (SARS-CoV-2)引起的。据报道,该病毒起源于蝙蝠,2019年在中国通过未知的中间动物传播给了人类。SARS-CoV-2比它的两个祖先SARS-CoV和中东呼吸综合征冠状病毒(MERS-CoV)传播得更快,但降低了致死率。目前,SARS-CoV-2已在全球造成约116万人死亡,确诊病例超过4340万例,对全球公众健康造成严重威胁,影响尚不明确。这种疾病通过吸入或直接与感染者接触传播。潜伏期由1至14天不等。新冠肺炎会伴有咳嗽、乏力等多种症状。对大多数人来说,这种疾病是轻微的,但在其他一些人,如老年人和慢性病患者,它可能从肺炎发展为多器官功能障碍。据报道,许多人无症状。病毒基因组已经测序,但有新的变异报告。它的结构和功能的许多生化方面被揭示。迄今为止,没有临床批准的疫苗和/或特定治疗药物可用于预防或治疗COVID-19。然而,有报道称,对SARS-CoV-2进行了密集的研究,已潜在地确定了疫苗和/或药物靶点,这可能有助于战胜该疾病。本文就SARS-CoV-2分子结构及其生化特性的研究进展作一综述。
关键词: COVID-19
Current Molecular Medicine
Title:Molecular Characterization of SARS-CoV-2
Volume: 21 Issue: 7
关键词: COVID-19
摘要: The coronavirus disease 2019 (COVID-19) is currently a new public health crisis threatening the world. This pandemic disease is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The virus has been reported to be originated in bats, and by yet unknown intermediary animals were transmitted to humans in China 2019. The SARS-CoV-2 spreads faster than its two ancestors, the SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV) but has reduced fatality. At present, the SARS-CoV-2 has caused about 1.16 million deaths with more than 43.4 million confirmed cases worldwide, resulting in a serious threat to public health globally with yet uncertain impact. The disease is transmitted by inhalation or direct contact with an infected person. The incubation period ranges from 1 to 14 days. COVID-19 is accompanied by various symptoms, including cough and fatigue. In most people, the disease is mild, but in some other people, such as in the elderly and people with chronic diseases, it may progress from pneumonia to a multi-organ dysfunction. Many people are reported asymptomatic. The virus genome is sequenced, but new variants are reported. Numerous biochemical aspects of its structure and function are revealed. To date, no clinically approved vaccines and/or specific therapeutic drugs are available to prevent or treat COVID-19. However, there are reported intensive researches on the SARS-CoV-2 to potentially identify vaccines and/or drug targets, which may help to overcome the disease. In this review, we discuss recent advances in understanding the molecular structure of SARS-CoV-2 and its biochemical characteristics.
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Cite this article as:
Molecular Characterization of SARS-CoV-2, Current Molecular Medicine 2021; 21 (7) . https://dx.doi.org/10.2174/1566524020999201203213037
DOI https://dx.doi.org/10.2174/1566524020999201203213037 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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