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Current Catalysis

Editor-in-Chief

ISSN (Print): 2211-5447
ISSN (Online): 2211-5455

Review Article

Application of Nitrogen Heterocyclic Carbenes in Organocatalysis

Author(s): Minita Ojha and R. K. Bansal*

Volume 10 , Issue 1 , 2021

Published on: 01 December, 2020

Page: [3 - 41] Pages: 39

DOI: 10.2174/2211544709999201201120617

Price: $65

Abstract

Background: During the last two decades, horizon of research in the field of Nitrogen Heterocyclic Carbenes (NHC) has widened remarkably. NHCs have emerged as ubiquitous species having applications in a broad range of fields, including organocatalysis and organometallic chemistry. The NHC-induced non-asymmetric catalysis has turned out to be a fruitful area of research in recent years.

Methods: By manipulating structural features and selecting appropriate substituent groups, it has been possible to control the kinetic and thermodynamic stability of a wide range of NHCs, which can be tolerant to a variety of functional groups and can be used under mild conditions. NHCs are produced by different methods, such as deprotonation of N-alkylhetrocyclic salt, transmetallation, decarboxylation and electrochemical reduction.

Results: The NHCs have been used successfully as catalysts for a wide range of reactions making a large number of building blocks and other useful compounds accessible. Some of these reactions are: benzoin condensation, Stetter reaction, Michael reaction, esterification, activation of esters, activation of isocyanides, polymerization, different cycloaddition reactions, isomerization, etc. The present review includes all these examples published during the last 10 years, i.e., from 2010 till date.

Conclusion: The NHCs have emerged as versatile and powerful organocatalysts in synthetic organic chemistry. They provide the synthetic strategy which does not burden the environment with metal pollutants and thus fits in the Green Chemistry.

Keywords: Nitrogen Heterocyclic carbenes, organocatalysts, benzoin condensation, cycloadditions, isomerization, esterification.

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