Abstract
Historically, the use of Iodinated Contrast Media (ICM) for diagnostic purposes, particularly radiography and Computed Tomography (CT), is well-known. Many of the ICM are included in the World Health Organization (WHO)’s List of Essential Medicines. Depending on the chemotype and the presence of ionizable functional group(s), the ICM are categorized into the ionic/nonionic monomers/dimers. The lipophilicity, aqueous solubility, viscosity and osmolality are major characteristics dictating their use for one procedure versus the other. Over the last several decades, substantial advancement has occurred in the design and development of novel ICM, solely to reduce their propensity to cause adverse effects. Given the nature of their acute usage, some of the agents with appreciable toxicity are still used. Understanding their chemistry aspects is crucial to appreciate, acknowledge and justify the usage of these extremely important torch-bearers of the diagnostic agent’s class. The present review article presents an in-depth overview of the synthetic methods, therapeutic indications, potential adverse effects along with the commercial and environmental aspects of ICM. The safety and tolerability of these agents is a field that has gained significant importance, which is given due importance in the discussion.
Keywords: Iodinated contrast media, radiography, diagnostic procedures, Computed Tomography (CT), X-rays, anatomic boundaries.
Mini-Reviews in Organic Chemistry
Title:Chemistry of Iodinated Contrast Media (ICM): A Mini Review
Volume: 18 Issue: 7
Author(s): Maithili P. Joshi, Ameya Chaudhari, Prashant S. Kharkar and Shreerang V. Joshi*
Affiliation:
- Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Nathalal Parekh Marg, Matunga, Mumbai 400019, Maharashtra,India
Keywords: Iodinated contrast media, radiography, diagnostic procedures, Computed Tomography (CT), X-rays, anatomic boundaries.
Abstract: Historically, the use of Iodinated Contrast Media (ICM) for diagnostic purposes, particularly radiography and Computed Tomography (CT), is well-known. Many of the ICM are included in the World Health Organization (WHO)’s List of Essential Medicines. Depending on the chemotype and the presence of ionizable functional group(s), the ICM are categorized into the ionic/nonionic monomers/dimers. The lipophilicity, aqueous solubility, viscosity and osmolality are major characteristics dictating their use for one procedure versus the other. Over the last several decades, substantial advancement has occurred in the design and development of novel ICM, solely to reduce their propensity to cause adverse effects. Given the nature of their acute usage, some of the agents with appreciable toxicity are still used. Understanding their chemistry aspects is crucial to appreciate, acknowledge and justify the usage of these extremely important torch-bearers of the diagnostic agent’s class. The present review article presents an in-depth overview of the synthetic methods, therapeutic indications, potential adverse effects along with the commercial and environmental aspects of ICM. The safety and tolerability of these agents is a field that has gained significant importance, which is given due importance in the discussion.
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Cite this article as:
Joshi P. Maithili , Chaudhari Ameya , Kharkar S. Prashant and Joshi V. Shreerang *, Chemistry of Iodinated Contrast Media (ICM): A Mini Review, Mini-Reviews in Organic Chemistry 2021; 18 (7) . https://dx.doi.org/10.2174/1570193X17666201127105348
DOI https://dx.doi.org/10.2174/1570193X17666201127105348 |
Print ISSN 1570-193X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6298 |
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