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Combinatorial Chemistry & High Throughput Screening

Editor-in-Chief

ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

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Editorial

Inhibitors of Monoamine Oxidase and Acetylcholinesterase as a Front Runner in CNS Drug Discovery

Author(s): Bijo Mathew and Hoon Kim

Volume 23, Issue 9, 2020

Page: [834 - 835] Pages: 2

DOI: 10.2174/138620732309201127093123

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[1]
Binda, C.; Mattevi, A.; Edmondson, D.E. Structural properties of human monoamine oxidases A and B. Int. Rev. Neurobiol., 2011, 100, 1-11.
[http://dx.doi.org/10.1016/B978-0-12-386467-3.00001-7] [PMID: 21971000]
[2]
Hubalek, F.; Pohl, J.; Edmondson, D.E. Structural comparison of human monoamine oxidases A and B: mass spectrometry monitoring of cysteine reactivities. J. Biol. Chem., 2003, 278(31), 28612-28618.
[http://dx.doi.org/10.1074/jbc.M303712200] [PMID: 12777388]
[3]
Mathew, B.; Mathew, G.E.; Suresh, J.; Ucar, G.; Sasidharan, R.; Vilapurathu, J.K.; Anbazhagan, S.; Jayaprakash, V. Monoamine oxidase inhibitors: Perspective design for the treatment of depression and, neurological disorders. Curr. Enzym. Inhib., 2016, 12, 115-122.
[http://dx.doi.org/10.2174/1573408012666160402001715]
[4]
Parambi, D.G.T.; Oh, J.M.; Baek, S.C.; Lee, J.P.; Tondo, A.R.; Nicolotti, O.; Kim, H.; Mathew, B. Design, synthesis and biological evaluation of oxygenated chalcones as potent and selective MAO-B inhibitors. Bioorg. Chem., 2019, 93103335
[http://dx.doi.org/10.1016/j.bioorg.2019.103335] [PMID: 31606547]
[5]
Müller, T.; Riederer, P.; Grünblatt, E. Determination of monoamine oxidase A and B activity in long-term treated patients with Parkinson disease. Clin. Neuropharmacol., 2017, 40(5), 208-211.
[http://dx.doi.org/10.1097/WNF.0000000000000233] [PMID: 28682929]
[6]
Mathew, B.; Parambi, D.G.T.; Mathew, G.E.; Uddin, M.S.; Inasu, S.T.; Kim, H. Emerging therapeutic potentials of dualacting MAO and AChE inhibitors in Alzheimer’s and Parkinson’s diseases. Arch. Pharm. Chem. Life Sci, 2019, 352e1900177
[http://dx.doi.org/10.1002/ardp.201900177]
[7]
Mathew, B.; Haridas, A.; Suresh, J.; Mathew, G.E.; Uçar, G.; Jayaprakash, V. Monoamine oxidase inhibitory actions of chalcones. A mini review. Cent. Nerv. Syst. Agents Med. Chem., 2016, 16(2), 120-136.
[http://dx.doi.org/10.2174/1871524915666151002124443] [PMID: 26429556]
[8]
Carradori, S.; Silvestri, R. New frontiers in selective human MAO-B inhibitors. J. Med. Chem., 2015, 58(17), 6717-6732.
[http://dx.doi.org/10.1021/jm501690r] [PMID: 25915162]

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