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Current Cardiology Reviews


ISSN (Print): 1573-403X
ISSN (Online): 1875-6557

Review Article

Potential Roles of MyomiRs in Cardiac Development and Related Diseases

Author(s): Leila Abkhooie, Mostafa M. Sarabi*, Houman Kahroba, Shirin Eyvazi, Soheila Montazersaheb, Vahideh Tarhriz* and Mohammad S. Hejazi

Volume 17 , Issue 4 , 2021

Published on: 24 November, 2020

Article ID: e010621188335 Pages: 14

DOI: 10.2174/1573403X16999201124201021

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Muscle-specific miRNAs, which are known as MyomiRs, are crucial regulatory elements for cardiovascular development. MyomiRs are abundantly expressed in the myocardium and regulate certain aspects of physiological and pathological processes in myocardiocytes, including cardiovascular development, myocardial remodeling, and arise for cardiovascular diseases through different mechanisms, such as epigenetic pathways. Clinical and experimental studies have confirmed the myomiRs as promising diagnostic biomarkers for the early diagnosis of cardiac disorders. In this review, we have summarized recent findings in the field of epigenetic modulations of myomiRs and cardiac regeneration associated with cardiac diseases.

Keywords: MyomiRs, epigenetic, cardiac development, cardiac diseases, microRNA, cardiac regeneration.

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