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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Electrochemical Immunosensors Based on Nanostructured Materials for Sensing of Prostate-Specific Antigen: A Review

Author(s): Hayati Filik*, Asiye Aslıhan Avan and Mustafa Özyürek

Volume 28 , Issue 20 , 2021

Published on: 24 November, 2020

Page: [4023 - 4048] Pages: 26

DOI: 10.2174/0929867328666201124151821

Price: $65


The prostate-specific antigen (PSA) has been considered a crucial serological marker for distinguishing prostate based cancer. This survey shows recent progress in the construction of nanomaterial-based electrochemical immunosensors for a PSA. This review (from 2015 to 2020) reports the latest progress in PSA sensing based on the employ of different types of nanostructured materials. The most popular used nanostructured materials are metal, metal oxide, carbon-based nanomaterials, and their hybrid architectures utilized for distinct amplification protocols. In this review, the electrochemical immunosensors for prostate-specific antigen sensing are classified into three categories such as sandwich type@labeled, label free@nonlabeled and aptamer-based electrochemical immunosensor.

Keywords: Prostate-specific antigen, cancer marker, immunosensor, immunoassay, nanomaterial, nanotechnology.

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