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Mini-Reviews in Organic Chemistry


ISSN (Print): 1570-193X
ISSN (Online): 1875-6298

Review Article

Structure-Activity Relationship of Supramolecular Compounds in Drug Delivery

Author(s): P. Rajalakshmi, Daniel N. Peter, Jesu Johnson S. and Nallamuthu Ananthi*

Volume 18, Issue 7, 2021

Published on: 23 November, 2020

Page: [961 - 989] Pages: 29

DOI: 10.2174/1570193X17999201123212536

Price: $65


Supramolecular compounds are capable of undergoing various non-covalent interactions with other molecules like host-guest chemistry, controlled encapsulation, hydrophobic interactions, a variety of delivering strategies, electron affinity induced interactions, etc. These properties of supramolecular compounds make them attractive to be effective drug carriers. This review will describe in detail the recent interesting reports on the structure-activity relationship of supramolecular compounds in drug delivery. The supramolecular compounds considered are cyclodextrins, cucurbiturils, avidin, biotin, rotaxanes, viologens, and dendrimers. Studying the opportunities given by these supramolecular compounds in drug delivery will pave the way for novel efficient drug delivery systems for the future.

Keywords: Supramolecular compounds, drug delivery, structure activity relationship, cyclodextrin, cucurbituril, avidin, biotin, rotaxane, viologen, dendrimer.

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