Generic placeholder image

Infectious Disorders - Drug Targets


ISSN (Print): 1871-5265
ISSN (Online): 2212-3989

Case Report

Coccidioidomycosis Resulting in a Prosthetic Joint Infection in an Immunocompetent Patient after a Total Hip Arthroplasty: A Case Report and Review of the Literature

Author(s): Sidra Shah, Syed Haq and Suresh J. Antony*

Volume 22, Issue 2, 2022

Article ID: e170322188282 Pages: 4

DOI: 10.2174/1871526520999201123205249

Price: $65


Introduction/Background: Coccidioidomycosis is a fungal infection that is a rare cause of prosthetic joint infection (PJI) in patients.

Case Presentation: This case report describes an immunocompetent patient who had a right total hip arthroplasty (THA) complicated with Coccidioidomycosis. This patient is the 9th reported case of Coccidioidomycosis, causing a PJI and only the second case to be reported in a THA. Once progressed, it can be difficult to treat, often reoccurring and requiring repeat surgical and prolonged therapy.

Conclusion: This study discusses the clinical presentation in this patient and reviews the literature on the currently published cases.

Keywords: Coccidioidomycosis, prosthetic joint infections, total hip arthroplasty, immunocompetent, immunosuppressive, antifungal therapy.

Graphical Abstract
Beam, E.; Osmon, D. Prosthetic joint infection update. Infect. Dis. Clin. North Am., 2018, 32(4), 843-859.
[] [PMID: 30241717]
Kao, A.S.; Brandt, M.E.; Pruitt, W.R.; Conn, L.A.; Perkins, B.A.; Stephens, D.S.; Baughman, W.S.; Reingold, A.L.; Rothrock, G.A.; Pfaller, M.A.; Pinner, R.W.; Hajjeh, R.A. The epidemiology of candidemia in two United States cities: results of a population-based active surveillance. Clin. Infect. Dis., 1999, 29(5), 1164-1170.
[] [PMID: 10524958]
Geng, L.; Xu, M.; Yu, L.; Li, J.; Zhou, Y.; Wang, Y.; Chen, J. Risk factors and the clinical and surgical features of fungal prosthetic joint infections: A retrospective analysis of eight cases. Exp. Ther. Med., 2016, 12(2), 991-999.
[] [PMID: 27446310]
Antony, S.; Domínguez, D.C.; Jackson, J.; Misenheimer, G. Evaluation and treatment of candida species in prosthetic joint infections: two case reports and review of the literature. Infect. Dis. Clin. Pract., 2008, 16(6), 354-359.
Lambertus, M.; Thordarson, D.; Goetz, M.B. Fungal prosthetic arthritis: presentation of two cases and review of the literature. Rev. Infect. Dis., 1988, 10(5), 1038-1043.
[] [PMID: 3055186]
Cooper, L.G.; Heydemann, J.; Misenhimer, G.; Antony, S. Use of intra-articular amphotericin b in the treatment of candida parasilosis and albicans in prosthetic joint infections (PJI): a novel approach to this difficult problem. Infect. Disord. Drug Targets, 2017, 17(1), 36-42.
[] [PMID: 27784234]
Wascher, D.C.; Hartman, G.P.; Salka, C.; Mertz, G.J. Coccidiomycosis presenting as a popliteal cyst. Arthroscopy, 1998, 14(1), 99-102.
[] [PMID: 9486343]
Kuberski, T.; Voichita, I.; Ferguson, T.; Nomura, J.; Johnson, R. Treatment of prosthetic joint infections associated with coccidioidomycosis: a review. Infect. Dis. Clin. Pract., 2011, 19, 252-255.
Austen, S.; van der Weegen, W.; Verduin, CM.; van der Valk, M.; Hoekstra, HJ. Coccidioidomycosis infection of a total knee arthroplasty in a nonendemic region J Arthroplasty , 2013, 28-2 (375 ), 13 -5 .
Arbeloa-Gutierrez, L.; Kuberski, T.; Johnson, S.M.; Sagastibelza, I.; Alaez, J.I.; Pappagianis, D. Reactivation of coccidioidomycosis: a prosthetic joint infection in Spain. Eur. J. Clin. Microbiol. Infect. Dis., 2016, 35(2), 183-186.
[] [PMID: 26638217]
Fiese, M.J. CoccidioidomycosisSpringfield 1958, 114, p137.

Rights & Permissions Print Export Cite as
© 2023 Bentham Science Publishers | Privacy Policy