摘要
早发型和晚发型阿尔茨海默病的分子遗传学研究 阿尔茨海默病(AD)是老年人中最常见的一种痴呆症,这种复杂的疾病与环境和遗传因素有关。早发性AD (EOAD)和晚发性AD (LOAD,更常见)是AD的主要鉴别类型。人们对EOAD的遗传学有广泛的了解,APP、PSEN1、PSEN2等三个基因变体导致了该疾病。一些常见的等位基因,包括载脂蛋白E,被有效地鉴定与负荷有关,但负荷的遗传学至今还不清楚。据估计,约有5-10%的EOAD患者可以通过EOAD的三个常见基因突变来解释。APOE ε4等位基因增加了携带者患EOAD风险的严重程度,APOE ε4等位基因被认为是EOAD的标志。大量没有基因解释的EOAD患者表明,目前还不可能确定引发疾病的基因。虽然已经在EOAD家族中使用下一代测序技术鉴定了几个基因,包括SORL1、TYROBP和NOTCH3。在EOAD患者中,通过外显子组测序发现了许多TYROBP变异体,这些TYROBP变异体可能增加EOAD的发病机制。ε4等位基因的存在是导致EOAD加重的原因。然而,一些ε4等位基因携带者提出了其他负荷遗传和环境风险因素的存在,目前尚未发现。迫切需要发现AD缺失的遗传学和负荷病因,发现新的潜在的遗传方面,这将有助于理解AD的病理机制。这些研究将有助于开发一种新的治疗候选者,以减轻、逆转和预防AD。本文在现有知识的基础上,综述了EOAD和LOAD的易感基因。接下来,我们将阐述可能阐明AD遗传病因的分子机制,并强调大规模平行测序技术在新基因发现中的作用。
关键词: 阿尔茨海默病,APP
Current Gene Therapy
Title:Molecular Genetics of Early- and Late-Onset Alzheimer’s Disease
Volume: 21 Issue: 1
关键词: 阿尔茨海默病,APP
摘要: Alzheimer’s disease (AD) is the most common form of dementia in the elderly and this complex disorder is associated with environmental as well as genetic factors. Early-onset AD (EOAD) and late-onset AD (LOAD, more common) are major identified types of AD. The genetics of EOAD is extensively understood, with three gene variants such as APP, PSEN1, and PSEN2 leading to the disease. Some common alleles, including APOE, are effectively associated with LOAD identified, but the genetics of LOAD is not clear to date. It has been accounted that about 5-10% of EOAD patients can be explained through mutations in the three familiar genes of EOAD. The APOE ε4 allele augmented the severity of EOAD risk in carriers, and the APOE ε4 allele was considered as a hallmark of EOAD. A great number of EOAD patients, who are not genetically explained, indicate that it is not possible to identify disease-triggering genes yet. Although several genes have been identified by using the technology of next-generation sequencing in EOAD families, including SORL1, TYROBP, and NOTCH3. A number of TYROBP variants are identified through exome sequencing in EOAD patients and these TYROBP variants may increase the pathogenesis of EOAD. The existence of the ε4 allele is responsible for increasing the severity of EOAD. However, several ε4 allele carriers propose the presence of other LOAD genetic as well as environmental risk factors that are not identified yet. It is urgent to find out missing genetics of EOAD and LOAD etiology to discover new potential genetic facets which will assist in understanding the pathological mechanism of AD. These investigations should contribute to developing a new therapeutic candidate for alleviating, reversing and preventing AD. This article, based on current knowledge, represents the overview of the susceptible genes of EOAD, and LOAD. Next, we represent the probable molecular mechanism that might elucidate the genetic etiology of AD and highlight the role of massively parallel sequencing technologies for novel gene discoveries.
Export Options
About this article
Cite this article as:
Molecular Genetics of Early- and Late-Onset Alzheimer’s Disease, Current Gene Therapy 2021; 21 (1) . https://dx.doi.org/10.2174/1566523220666201123112822
DOI https://dx.doi.org/10.2174/1566523220666201123112822 |
Print ISSN 1566-5232 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5631 |
Call for Papers in Thematic Issues
Programmed Cell Death Genes in Oncology: Pioneering Therapeutic and Diagnostic Frontiers (BMS-CGT-2024-HT-45)
Programmed Cell Death (PCD) is recognized as a pivotal biological mechanism with far-reaching effects in the realm of cancer therapy. This complex process encompasses a variety of cell death modalities, including apoptosis, autophagic cell death, pyroptosis, and ferroptosis, each of which contributes to the intricate landscape of cancer development and ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Respiratory Gas Exchange During Exercise in Children with Congenital Heart Disease: Methodology and Clinical Concepts
Current Respiratory Medicine Reviews Drugs Targeting the Canonical NF-κB Pathway to Treat Viral and Autoimmune Myocarditis
Current Pharmaceutical Design Device Therapies: New Indications and Future Directions
Current Cardiology Reviews The Malignant Obesity Hypoventilation Syndrome (MOHS)
Current Respiratory Medicine Reviews Cardiac (myo)fibroblast: Novel Strategies for its Targeting Following Myocardial Infarction
Current Pharmaceutical Design Electrotransfer into Skeletal Muscle for Protein Expression
Current Gene Therapy Functional Relevance of Biased Signaling at the Angiotensin II Type 1 Receptor
Endocrine, Metabolic & Immune Disorders - Drug Targets Repositioning of Drugs in Cardiometabolic Disorders: Importance and Current Scenario
Current Topics in Medicinal Chemistry Cellular Therapy for Myocardial Repair
Current Cardiology Reviews Demystifying the ACE Polymorphism: From Genetics to Biology
Current Pharmaceutical Design Clinical Impacts in Cardiovascular Molecular Imaging: the Example of Cardiac Sympathetic Imaging in Heart Failure
Current Medical Imaging Chemistry and Pharmacological Properties of Some Natural and Synthetic Antioxidants for Heavy Metal Toxicity
Current Medicinal Chemistry ALDH2---The Genetic Polymorphism and Enzymatic Activity Regulation: Their Epidemiologic and Clinical Implications
Current Drug Targets Free Fatty Acids: Circulating Contributors of Metabolic Syndrome
Cardiovascular & Hematological Agents in Medicinal Chemistry Matrix Metalloproteinase Knockout Studies and the Potential Use of Matrix Metalloproteinase Inhibitors in the Rheumatic Diseases
Current Drug Targets - Inflammation & Allergy Pediatric Immune Dysfunction and Health Risks Following Early-Life Immune Insult
Current Pediatric Reviews Challenges in Chagas Disease Drug Discovery: A Review
Current Medicinal Chemistry The Effect of Licorice Drink on the Systemic Exposure of Verapamil in Rabbits
Drug Metabolism Letters Mechanisms of Intimal Hyperplasia Learned from a Murine Carotid Artery Ligation Model
Current Vascular Pharmacology Potential Role of TRAIL in the Management of Autoimmune Diabetes Mellitus
Current Pharmaceutical Design