Abstract
Gastric cancer is the second most common cause of cancer-related deaths in the world. The surgical management of the tumor is the best therapeutic option for gastric cancer patients. A combination of a heterogeneous distribution of genetic and environmental factors appears to be required to explain patients' poor prognosis. A search for targeted and molecular-based approaches is affected by the optimal gastric cancer drug management. The modern multidisciplinary approach to treating the pathology used worldwide prolongs the overall patient survival and decreases the rate of recurrence. An understanding of the mechanisms that underlie therapies will provide new insights into gastric cancer treatment. The improvement in medicine will probably be associated with a study of tumor biology, followed by a personalized and molecular-based approach development in anticancer drugs administration. The modern perspective in gastric cancer detection and treatment is the application of nanoparticles. Nanoparticles affecting the intensity of biological processes in cancer cells can be used to treat cancers to increase the effectiveness of anti-tumor therapy. Their cytotoxicity involves a wide range of pathological events. Their targets are the extracellular matrix degradation, epithelial-mesenchymal transition, tumor angiogenesis, tumor microenvironment modulation. These are accompanied by lipid peroxidation, apoptosis, and autophagic flux. Preliminary studies on the efficacy of the use of nanoparticles in cultured gastric cancers open new opportunities for anti-tumor treatment to overcome the toxicity of therapeutic agents and decrease the rate of resistance to anticancer drugs and therapies.
Keywords: Nanoparticles, molecular mechanism of anticancer action, apoptosis, autophagy, reactive oxygen species, gastric cancer, molecular typing, resistance to therapy.
Current Pharmaceutical Design
Title:Nanoparticles in Gastric Cancer Management
Volume: 27 Issue: 21
Author(s): Alexandra V. Avgustinovich, Olga V. Bakina*, Sergey G. Afanas’ev, Olga V. Cheremisina, Liudmila V. Spirina, Alexey Y. Dobrodeev, Michail Buldakov and Evgeny L. Choynzonov
Affiliation:
- Institute of Strength Physics and Materials Science of the Siberian Branch of the Russian Academy of Sciences, 2/4, pr. Akademicheskii, Tomsk, 634055,Russian Federation
Keywords: Nanoparticles, molecular mechanism of anticancer action, apoptosis, autophagy, reactive oxygen species, gastric cancer, molecular typing, resistance to therapy.
Abstract: Gastric cancer is the second most common cause of cancer-related deaths in the world. The surgical management of the tumor is the best therapeutic option for gastric cancer patients. A combination of a heterogeneous distribution of genetic and environmental factors appears to be required to explain patients' poor prognosis. A search for targeted and molecular-based approaches is affected by the optimal gastric cancer drug management. The modern multidisciplinary approach to treating the pathology used worldwide prolongs the overall patient survival and decreases the rate of recurrence. An understanding of the mechanisms that underlie therapies will provide new insights into gastric cancer treatment. The improvement in medicine will probably be associated with a study of tumor biology, followed by a personalized and molecular-based approach development in anticancer drugs administration. The modern perspective in gastric cancer detection and treatment is the application of nanoparticles. Nanoparticles affecting the intensity of biological processes in cancer cells can be used to treat cancers to increase the effectiveness of anti-tumor therapy. Their cytotoxicity involves a wide range of pathological events. Their targets are the extracellular matrix degradation, epithelial-mesenchymal transition, tumor angiogenesis, tumor microenvironment modulation. These are accompanied by lipid peroxidation, apoptosis, and autophagic flux. Preliminary studies on the efficacy of the use of nanoparticles in cultured gastric cancers open new opportunities for anti-tumor treatment to overcome the toxicity of therapeutic agents and decrease the rate of resistance to anticancer drugs and therapies.
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Cite this article as:
Avgustinovich V. Alexandra , Bakina V. Olga *, Afanas’ev G. Sergey, Cheremisina V. Olga , Spirina V. Liudmila , Dobrodeev Y. Alexey , Buldakov Michail and Choynzonov L. Evgeny , Nanoparticles in Gastric Cancer Management, Current Pharmaceutical Design 2021; 27 (21) . https://dx.doi.org/10.2174/1381612826666201120155120
DOI https://dx.doi.org/10.2174/1381612826666201120155120 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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