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当代肿瘤药物靶点

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Research Article

抑制性分子的T细胞活化的同时表达预测食管鳞状细胞癌患者的生存率较差。

卷 21, 期 3, 2021

发表于: 20 November, 2020

页: [244 - 253] 页: 10

弟呕挨: 10.2174/1568009620666201120152333

价格: $65

摘要

背景：食管鳞状细胞癌（ESCC）是食管癌的主要亚型。 ESCC的五年生存率很低，并且用于ESCC治疗和预后评估的分子靶标非常有限。 T细胞对于清除癌细胞至关重要，而抑制T细胞活化的共抑制分子已成为治疗癌症患者的有前途的疗法。然而，在ESCC患者中，调控T细胞活化的共抑制分子的文献报道很少。 目的：我们旨在评估T细胞中抑制性检查点分子的存在如何影响患者的生存。 方法：我们对2014年2月至2015年12月接受食管癌切除的161例患者进行了随访研究，方法是对6种抑制T细胞活化的共抑制分子，即PD-1，CTLA-4，TIM-3进行免疫组织化学染色。 LAG-3，BTLA和A2AR。通过Kaplan-Meier生存分析分析了六个共抑制分子中每一个的表达与患者生存的相关性。我们还应用Kaplan-Meier分析来评估共抑制分子的伴随表达及其与患者生存率的相关性。 结果：我们发现PD-1，TIM-3和BTLA的水平可以用作ESCC患者总体生存的独立预后因素。更重要的是，我们的研究发现PD-1和TIM-3，PD-1和BTLA，TIM-3和BTLA的共表达显着降低了食管鳞癌患者的生存率（P <0.05）。 结论：因此，我们的结果表明在ESCC患者的免疫治疗中评估肿瘤组织中共抑制分子和靶向共表达分子的必要性。

关键词: ESCC，T细胞，PD-1，TIM-3，BTLA，存活率。

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