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Current Rheumatology Reviews


ISSN (Print): 1573-3971
ISSN (Online): 1875-6360

Research Article

Cytotoxic T Lymphocyte Antigen 4 Gene +49 A/G (rs231775) Polymorphism and Susceptibility to Systemic Lupus Erythematosus

Author(s): Rania Mohammed Kishk, Maii Abdelraheem Abdellatif, Raghda Elsawi Eldesouki*, Mohamed Fawzy, Shaymaa Abdelraheem Abdelhady and Marwa Mohamed Fouad

Volume 17, Issue 2, 2021

Published on: 19 November, 2020

Page: [247 - 251] Pages: 5

DOI: 10.2174/1573397116666201119145153

Price: $65


Aim: To assess the probable role of +49AG polymorphism in susceptibility to SLE in an Egyptian population.

Background: Systemic lupus erythematosus (SLE) is a compound inflammatory chronic disease distinguished through the release of autoantibodies. Cytotoxic T lymphocyte associated antigen-4 is a main down controller of T-cell response; its dysregulation could affect SLE pathogenesis by altered T cells activation to self-antigens.

Objectives: To evaluate the CTLA-4 +49AG allelic and genotype frequency in a sample of the Egyptian population and correlate them with disease susceptibility and clinical severity.

Materials and methods: Including 100 patients with SLE and 100 healthy controls (age and gender matched), CTLA-4 exon 1 49 A>G Genotyping was done using Real-Time PCR.

Results: No difference was noticed in genotype or allele distributions of the studied polymorphism between both groups. Similar genotypes and allele frequencies were established for the 2 groups after their stratification by the age of disease onset, clinical course, or severity.

Conclusion: CTLA-4 +49AG gene polymorphism is not linked with the liability to develop SLE in the studied Egyptian population. Yet it is significantly related to disease severity.

Keywords: Systemic lupus polymorphisms, CTLA-4, SNP genotyping, (rs231775), (+49 A/G), PCR.

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