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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Review Article

Therapeutic Potential of Equol: A Comprehensive Review

Author(s): Atiya Fatima*, Mohd Shariq Khan and Md. Wasi Ahmad*

Volume 26, Issue 45, 2020

Page: [5837 - 5843] Pages: 7

DOI: 10.2174/1381612826999201117122915

Price: $65


Equol (4',7-isoflavandiol), is a phytoestrogenic compound, which is synthesized from parent molecule diadzein by intestinal bacterial flora. It is among one of the most extensively researched molecule due to its high affinity towards estrogen receptors. Its enantiomeric form S-equol has been explored in the treatment of estrogen/androgen mediated diseases. Various therapeutic applications such as anti-cancer, cardioprotective, antidiabetic, antiosteoporosis, anti-ageing, and neuroprotective efficacy are attributed to it. This review explored major studies related to biochemistry and pharmacological applications of equol for human health.

Keywords: Bioactive molecule, equol, S-equol, isoflavone, nutraceutical, phytoestrogen, selective estrogen receptor modulator (SERM).

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