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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Mini-Review Article

Coumarins as Potential Anti-drug Resistant Cancer Agents: A Mini Review

Author(s): Gangqiang Wang, Shaofa Sun, Bin Wu and Jikai Liu*

Volume 21, Issue 19, 2021

Published on: 13 November, 2020

Page: [1725 - 1736] Pages: 12

DOI: 10.2174/1568026620999201113110041

Price: $65


Cancer is the main cause of death, and the emergence of resistance by cancer cells towards existing anticancer agents is one of the major problems for effective chemotherapy, creating a great demand for the development of novel anticancer drugs. Coumarins, abundantly found in nature, constitute an important class of pharmacological agents possessing physiological activities. The mechanism investigations elucidated that coumarins could lead to self-programmed cancer cell death (apoptosis) via different mechanisms; thereby coumarin-based derivatives possess potential activity against various forms of cancers, including drug-resistant, even multidrug-resistant cancers. This review article describes the recent progress in the discovery, structural modification, structure-activity relationship, and mechanism of action studies of coumarin-based derivatives with potential activity against drug-resistant cancers, covering articles published between 2010 and 2020.

Keywords: Coumarin, Natural product, Hybrid compounds, Cancer, Drug resistance, Mechanism of action.

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