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Current Biotechnology


ISSN (Print): 2211-5501
ISSN (Online): 2211-551X

Review Article

Conventional Plastics' Harmful Effects and Biological and Molecular Strategies for Biodegradable Plastics' Production

Author(s): Felipe S. Edaes* and Cleide B. de Souza

Volume 9 , Issue 4 , 2020

Page: [242 - 254] Pages: 13

DOI: 10.2174/2211550109999201113102157

Price: $65


Background: Plastic materials are ubiquitous and, despite the great benefits and advantages that the materials provide to human beings and society, their harmful effects are remarkable. Plastics’ ingestion is harmful and can occur through microplastics and their by-products (BPA and DEHP). It can trigger health problems. Also, the material decomposition time is significant and consequently, plastic waste accumulates in the environment, posing a major problem to fauna and flora.

Objectives: The aim of this study is to develop a review of conventional plastics’ negative aspect in human and environmental life, as well as to study the existing biological and molecular strategies for the production of biodegradable plastics, making a comparison of their advantages over conventional plastics, in favor of socio-environmental welfare.

Methods: In this review, articles published in the last 20 years related to different aspects of conventional plastics and biodegradable plastics were accurately analyzed and reviewed. The subjects addressed ranged from conventional plastics and the problems related to their large-scale production, as well as biodegradable plastics, their advantages and the most recent advances in the development of production methods and improvement of these biopolymers were extensively reviewed and discussed concisely.

Results: The present study demonstrated that, among the biopolymers discussed, thermoplastic starch (TPS) is the most promising one due to its low cost, being one of the best materials to provide a viable alternative in the search for biodegradable plastics. Polylactic acid (PLA) presents the greatest potential for future medical applications due to its unique physicochemical properties and the possibility of being used in 3D printing techniques.Polyhydroxyalkanoates (PHAs) have the greatest commercial potential in replacing fossil fuel-based plastics because of their similar properties to conventional plastics and because they are synthesized by microorganisms from renewable carbon sources.

Conclusion: This study demonstrated the various harmful effects that the large-scale use and improper disposal of conventional plastic materials generated to the environment and human health, and proposed an alternative to this problem, the biodegradable plastics. Although this study presented three promising biodegradable plastics (TPS, PLA and PHAs), as well as described their production methods, there are currently no viable biodegradable plastic polymers that can be used for the total replacement of conventional plastics, especially from an economic perspective. However, in the future, modifications in the production methods and chemical structures of these polymers will allow the replacement of conventional plastics by biodegradable plastics, as well as a more extensive application of these biopolymers.

Keywords: Environment, ecotoxicology, plastics, biodegradable plastics, biotechnology, culturally appropriate technology.

Graphical Abstract
North EJ, Halden RU. Plastics and environmental health: The road ahead. Rev Environ Health 2013; 28(1): 1-8.
[] [PMID: 23337043]
Shafei A, Ramzy MM, Hegazy AI, et al. The molecular mechanisms of action of the endocrine disrupting chemical bisphenol A in the development of cancer. Gene 2018; 647: 235-43.
[] [PMID: 29317319]
Florez JP, Fazeli M, Simão RA. Preparation and characterization of thermoplastic starch composite reinforced by plasma-treated poly (hydroxybutyrate) PHB. Int J Biol Macromol 2019; 123: 609-21.
[] [PMID: 30447362]
Hossein Rashidi B, Amanlou M, Behrouzi Lak T, et al. The association between bisphenol A and polycystic ovarian syndrome: A case-control study. Acta Med Iran 2017; 55(12): 759-64.
[PMID: 29373882]
Molina A, Abril N, Morales-Prieto N, et al. Hypothalamic-pituitary-ovarian axis perturbation in the basis of bisphenol A (BPA) reproductive toxicity in female zebrafish (Danio rerio). Ecotoxicol Environ Saf 2018; 156: 116-24.
[] [PMID: 29549734]
Edaes FS, Ribeiro SM, de Souza CB. Bisphenol a hazards in human health and environment ruep 2019; 15(41): 146-61. Available from:
Haward M. Plastic pollution of the world’s seas and oceans as a contemporary challenge in ocean governance. Nat Commun 2018; 9(1): 667.
[] [PMID: 29445166]
Samper MD, Bertomeu D, Arrieta MP, Ferri JM, López-Martínez J. Interference of biodegradable plastics in the polypropylene recycling process. Materials (Basel) 2018; 11(10): 1886.
[] [PMID: 30279367]
Gigante V, Canesi I, Cinelli P, Coltelli MB, Lazzeri A. Rubber toughening of polylactic acid (PLA) with poly(butylene adipateco- terephthalate) (PBAT): Mechanical properties, fracture mechanics and analysis of ductile-to-brittle behavior while varying temperature and test speed. Eur Polym J 2019; 115: 125-37.
Mannina G, Presti D, Montiel-Jarillo G, Suárez-Ojeda ME. Bioplastic recovery from wastewater: A new protocol for polyhydroxyalkanoates (PHA) extraction from mixed microbial cultures. Bioresour Technol 2019; 282: 361-9.
[] [PMID: 30884455]
Zhong Y, Godwin P, Jin Y, Xiao H. Biodegradable polymers and green-based antimicrobial packaging materials: A mini-review. Adv Ind Eng Polym Res 2020; 3(1): 27-35.
Ogunrinola TM, Akpan UG. Production of cassava starch bioplastic film reinforced with poly-Lactic acid (PLA). IJERAT 2018; 4(8): 56-61.
Koppolu R, Lahti J, Abitbol T, Swerin A, Kuusipalo J, Toivakka M. Continuous processing of nanocellulose and polylactic acid into multilayer barrier coatings. ACS Appl Mater Interfaces 2019; 11(12): 11920-7.
[] [PMID: 30829474]
Zuo X, Xue Y, Zhou Y, Yin Y, Li T-D, Wang L, et al. The use of low cost, abundant, homopolymers for engineering degradable polymer blends: Compatibilization of poly(lactic acid)/styrenics using poly(methyl methacrylate). Polymer (Guildf) 2020; 186: 122010.
Wang Y, Chung A, Chen G-Q. Synthesis of medium-chain-length polyhydroxyalkanoate homopolymers, random copolymers, and block copolymers by an engineered strain. Adv Healthc Mater 2017; 6(7): 1601017.
[] [PMID: 28128887]
Thompson RC, Moore CJ, vom Saal FS, Swan SH. Plastics, the environment and human health: Current consensus and future trends. Philos Trans R Soc Lond B Biol Sci 2009; 364(1526): 2153-66.
[] [PMID: 19528062]
Yang Y, Yang J, Wu W-M, et al. Biodegradation and mineralization of polystyrene by plastic-eating mealworms: Part 2. Role of gut microorganisms. Environ Sci Technol 2015; 49(20): 12087-93.
[] [PMID: 26390390]
Alam O, Wang S, Lu W. Heavy metals dispersion during thermal treatment of plastic bags and its recovery. J Environ Manage 2018; 212: 367-74.
[] [PMID: 29455145]
Andrady AL, Neal MA. Applications and societal benefits of plastics. Philos Trans R Soc Lond B Biol Sci 2009; 364(1526): 1977-84.
[] [PMID: 19528050]
Vert M. Not any new functional polymer can be for medicine: What about artificial biopolymers? Macromol Biosci 2011; 11(12): 1653-61.
[] [PMID: 22052691]
Saratale RG, Saratale GD, Cho SK, et al. Pretreatment of kenaf (Hibiscus cannabinus L.) biomass feedstock for polyhydroxybutyrate (PHB) production and characterization. Bioresour Technol 2019; 282: 75-80.
[] [PMID: 30851577]
De Falco F, Di Pace E, Cocca M, Avella M. The contribution of washing processes of synthetic clothes to microplastic pollution. Sci Rep 2019; 9(1): 6633.
[] [PMID: 31036862]
Manavitehrani I, Fathi A, Badr H, Daly S, Negahi Shirazi A, Dehghani F. Biomedical applications of biodegradable polyesters. Polymers (Basel) 2016; 8(1): 20.
[] [PMID: 30979116]
Mullan M. Science and technology of modified atmosphere packaging 2011. Available from:
1. Marsh G. Composites flying high. Reinforced Plastics 2014; 58(3): 14-8.
Sivan A. New perspectives in plastic biodegradation. Curr Opin Biotechnol 2011; 22(3): 422-6.
[] [PMID: 21356588]
Barnes DKA, Galgani F, Thompson RC, Barlaz M. Accumulation and fragmentation of plastic debris in global environments. Philos Trans R Soc Lond B Biol Sci 2009; 364(1526): 1985-98.
[] [PMID: 19528051]
Frias JPGL, Sobral P, Ferreira AM. Organic pollutants in microplastics from two beaches of the Portuguese coast. Mar Pollut Bull 2010; 60(11): 1988-92.
[] [PMID: 20800853]
Peng X, Zheng K, Liu J, Fan Y, Tang C, Xiong S. Body size-dependent bioaccumulation, tissue distribution, and trophic and maternal transfer of phenolic endocrine-disrupting contaminants in a freshwater ecosystem. Environ Toxicol Chem 2018; 37(7): 1811-23.
[] [PMID: 29663490]
Harding S. Marine debris: Understanding, preventing and mitigating the significant adverse impacts on marine and coastal biodiversity. 83rd ed. Montreal: Secretariat of the convention on biological diversity 2016. [cited 2018 Jul 15] Available from:
United Nations Environment Programme. Towards a pollution-free planet background report 2017. Available from:
Liao C, Liu F, Kannan K. Bisphenol s, a new bisphenol analogue, in paper products and currency bills and its association with bisphenol a residues. Environ Sci Technol 2012; 46(12): 6515-22.
[] [PMID: 22591511]
Rochester JR, Bolden AL, Bisphenol S. A systematic review and comparison of the hormonal activity of bisphenol a substitutes. Environ Health Perspect 2015; 123(7): 643-50.
[] [PMID: 25775505]
Fromme H, Küchler T, Otto T, Pilz K, Müller J, Wenzel A. Occurrence of phthalates and bisphenol A and F in the environment. Water Res 2002; 36(6): 1429-38.
[] [PMID: 11996333]
Liao C, Liu F, Alomirah H, et al. Bisphenol S in urine from the United States and seven Asian countries: Occurrence and human exposures. Environ Sci Technol 2012; 46(12): 6860-6.
[] [PMID: 22620267]
Yang Y, Lu L, Zhang J, Yang Y, Wu Y, Shao B. Simultaneous determination of seven bisphenols in environmental water and solid samples by liquid chromatography-electrospray tandem mass spectrometry. J Chromatogr A 2014; 1328: 26-34.
[] [PMID: 24411090]
Zhu M, Chen X-Y, Li Y-Y, et al. Bisphenol F disrupts thyroid hormone signaling and postembryonic development in Xenopus laevis. Environ Sci Technol 2018; 52(3): 1602-11.
[] [PMID: 29323886]
Viñas R, Watson CS, Bisphenol S. Bisphenol S disrupts estradiol-induced nongenomic signaling in a rat pituitary cell line: Effects on cell functions. Environ Health Perspect 2013; 121(3): 352-8.
[] [PMID: 23458715]
Eladak S, Grisin T, Moison D, et al. A new chapter in the bisphenol A story: Bisphenol S and bisphenol F are not safe alternatives to this compound. Fertil Steril 2015; 103(1): 11-21.
[] [PMID: 25475787]
Hopewell J, Dvorak R, Kosior E. Plastics recycling: Challenges and opportunities. Philos Trans R Soc Lond B Biol Sci 2009; 364(1526): 2115-26.
[] [PMID: 19528059]
Fu P, Kawamura K. Ubiquity of bisphenol A in the atmosphere. Environ Pollut 2010; 158(10): 3138-43.
[] [PMID: 20678833]
Ogunola OS, Onada OA, Falaye AE. Mitigation measures to avert the impacts of plastics and microplastics in the marine environment (a review). Environ Sci Pollut Res Int 2018; 25(10): 9293-310.
[] [PMID: 29470754]
PlasticsEurope. The Compelling Facts About Plastics: An analysis of plastics production, demand and recovery for 2006 in Europe 17th ed. 2008. Available from:
Haider TP, Völker C, Kramm J, Landfester K, Wurm FR. Plastics of the future? The impact of biodegradable polymers on the environment and on society. Angew Chem Int Ed Engl 2019; 58(1): 50-62.
[] [PMID: 29972726]
Eriksen M, Maximenko N, Thiel M, et al. Plastic pollution in the South Pacific subtropical gyre. Mar Pollut Bull 2013; 68(1-2): 71-6.
[] [PMID: 23324543]
Ballance A, Ryan PG, Turpie JK. How much is a clean beach worth? The impact of litter on beach users in the Cape Peninsula, South Africa. S Afr J Sci 2018; 96(5): 210-3.
European Commission. A European strategy for plastics in a circular economy 2018. Available from:
Soares E. City of Rio de Janeiro bans plastic straws 2018. Available from:
Loizidou XI, Loizides MI, Orthodoxou DL. Persistent marine litter: Small plastics and cigarette butts remain on beaches after organized beach cleanups. Environ Monit Assess 2018; 190(7): 414.
[] [PMID: 29926242]
Shawaphun S, Manangan T, Wacharawichanant S. Thermo- and photo-degradation of LDPE and PP films using metal oxides as catalysts. AMR 2010; 93-94: 505-8.
Barlow CY, Morgan DC. Polymer film packaging for food: An environmental assessment. Resour Conserv Recycling 2013; 78: 74-80.
Wagner TP. Reducing single-use plastic shopping bags in the USA. Waste Manag 2017; 70: 3-12.
[] [PMID: 28935376]
Nielsen TD, Holmberg K, Stripple J. Need a bag? A review of public policies on plastic carrier bags - Where, how and to what effect? Waste Manag 2019; 87: 428-40.
[] [PMID: 31109543]
Broeren MLM, Kuling L, Worrell E, Shen L. Environmental impact assessment of six starch plastics focusing on wastewater-derived starch and additives. Resour Conserv Recycling 2017; 127: 246-55.
Bugnicourt E, Cinelli P, Lazzeri A, Alvarez V. Polyhydroxyalkanoate (PHA): Review of synthesis, characteristics, processing and potential applications in packaging. Express Polym Lett 2014; 8(11): 791-808.
Sukruansuwan V, Napathorn SC. Use of agro-industrial residue from the canned pineapple industry for polyhydroxybutyrate production by Cupriavidus necator strain A-04. Biotechnol Biofuels 2018; 11(1): 202.
[] [PMID: 30061924]
Mohammadi Nafchi A, Moradpour M, Saeidi M, Alias AK. Thermoplastic starches: Properties, challenges, and prospects. Starke 2013; 65(1-2): 61-72.
Jayasekara R, Harding I, Bowater I, Lonergan G. Biodegradability of a selected range of polymers and polymer blends and standard methods for assessment of biodegradation. J Polym Environ 2005; 13(3): 231-51.
Valentina I, Haroutioun A, Fabrice L, Vincent V, Roberto P. Poly(lactic acid)-based nanobiocomposites with modulated degradation rates. Materials (Basel) 2018; 11(10): 1943-61.
[] [PMID: 30314349]
Kim M, Jeong JH, Lee J-Y, et al. Electrically conducting and mechanically strong graphene-polylactic acid composites for 3D printing. ACS Appl Mater Interfaces 2019; 11(12): 11841-8.
[] [PMID: 30810305]
Shojaeiarani J, Bajwa DS, Stark NM, Bajwa SG. Rheological properties of cellulose nanocrystals engineered polylactic acid nanocomposites. Compos, Part B Eng 2019; 161: 483-9.
Muller J, González-Martínez C, Chiralt A. Combination of poly(lactic) acid and starch for biodegradable food packaging. Materials (Basel) 2017; 10(8): 952.
[] [PMID: 28809808]
Chek MF, Hiroe A, Hakoshima T, Sudesh K, Taguchi S. PHA synthase (PhaC): Interpreting the functions of bioplastic-producing enzyme from a structural perspective. Appl Microbiol Biotechnol 2019; 103(3): 1131-41.
[] [PMID: 30511262]
Karmann S, Panke S, Zinn M. Fed-batch cultivations of Rhodospirillum rubrum under multiple nutrient-limited growth conditions on syngas as a novel option to produce poly(3-Hydroxybutyrate) (PHB). Front Bioeng Biotechnol 2019; 7: 59.
[] [PMID: 31001525]
Urtuvia V, Villegas P, González M, Seeger M. Bacterial production of the biodegradable plastics polyhydroxyalkanoates. Int J Biol Macromol 2014; 70: 208-13.
[] [PMID: 24974981]
da Silva Moura A, Demori R, Leão RM, Crescente Frankenberg CL, Campomanes Santana RM. The influence of the coconut fiber treated as reinforcement in PHB (polyhydroxybutyrate) composites. Mater Today Commun 2019; 18: 191-8.
Dilkes-Hoffman LS, Lant PA, Laycock B, Pratt S. The rate of biodegradation of PHA bioplastics in the marine environment: A meta-study. Mar Pollut Bull 2019; 142: 15-24.
[] [PMID: 31232288]
Mohamad Fauzi AH, Chua ASM, Yoon LW, Nittami T, Yeoh HK. Enrichment of PHA-accumulators for sustainable PHA production from crude glycerol. Process Saf Environ Prot 2019; 122: 200-8.
Saranya V, Shenbagarathai R. Production and characterization of PHA from recombinant E. coli harbouring phaC1 gene of indigenous Pseudomonas sp. LDC-5 using molasses. Braz J Microbiol 2011; 42(3): 1109-18.
[] [PMID: 24031729]
Bengtsson S, Karlsson A, Alexandersson T, et al. A process for polyhydroxyalkanoate (PHA) production from municipal wastewater treatment with biological carbon and nitrogen removal demonstrated at pilot-scale. N Biotechnol 2017; 35: 42-53.
[] [PMID: 27915059]
Chen Z, Huang L, Wen Q, Zhang H, Guo Z. Effects of sludge retention time, carbon and initial biomass concentrations on selection process: From activated sludge to polyhydroxyalkanoate accumulating cultures. J Environ Sci (China) 2017; 52: 76-84.
[] [PMID: 28254060]
Villano M, Valentino F, Barbetta A, Martino L, Scandola M, Majone M. Polyhydroxyalkanoates production with mixed microbial cultures: From culture selection to polymer recovery in a high-rate continuous process. N Biotechnol 2014; 31(4): 289-96.
[] [PMID: 23954657]
Gholami A, Mohkam M, Rasoul-Amini S, Ghasemi Y. Industrial production of polyhydroxyalkanoates by bacteria: Opportunities and challenges. Minerva Biotecnol 2016; 28(1): 59-74.
Singh AK, Srivastava JK, Chandel AK, Sharma L, Mallick N, Singh SP. Biomedical applications of microbially engineered polyhydroxyalkanoates: An insight into recent advances, bottlenecks, and solutions. Appl Microbiol Biotechnol 2019; 103(5): 2007-32.
[] [PMID: 30645689]
Mao C, Feng Y, Wang X, Ren G. Review on research achievements of biogas from anaerobic digestion. Renew Sustain Energy Rev 2015; 45: 540-55.
Soto LR, Byrne E, van Niel EWJ, Sayed M, Villanueva CC, Hatti-Kaul R. Hydrogen and polyhydroxybutyrate production from wheat straw hydrolysate using Caldicellulosiruptor species and Ralstonia eutropha in a coupled process. Bioresour Technol 2019; 272: 259-66.
[] [PMID: 30352368]

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