The Molecular Diversity of 1,8-diaminonaphthalene in Organic Chemistry

Title:The Molecular Diversity of 1,8-diaminonaphthalene in Organic Chemistry

Volume: 24 Issue: 10

Author(s): Ghodsi Mohammadi Ziarani*, Fatemeh Mohajer and Suraj N. Mali

Affiliation:

• Department of Physics and Chemistry, Faculty of Science, University of Alzahra, Vanak Square, 1993893973, Tehran,Iran

Keywords: 1, 8-diaminonaphthalene (1, 8-DAN), perimidines, dihydro perimidines, perimidones, Different amino scaffold, molecular diversity.

Abstract:

Background: 1,8-diaminonaphthalen (1,8-DAN) with special organic structure was applied in organic synthesis to provide efficient complex scaffolds, through the two or fourcomponent fashion. This review highlights its recent application in organic reactions under different conditions and heterogynous catalysts to produce various molecules, which were used as medicines, sensors, and dyes.

Objective: 1,8-diaminonaphthalene (1,8-DAN) is a bicyclic compound with two amino groups which has received much attention in organic chemistry due to their medicinal activities such as antifungal, antimicrobial, antiulcer, antitumor, oxidation dyestuff, hair color, fluorescent, and chemo-sensors. In continuation of our studies, herin, recent application of 1,8-DAN in organic synthesis was reviewed.

Conclusion: In conclusion, the application of 1,8-DAN 1 in different reactions was reviewd through the various conditions to yield the target compounds with high medicinal activities, and potential for sensitive detection of different ions. The target compounds including 1,8-DAN 1 with various structures were provided such as perimidines, perimidinones, aminonaphthalenes which were produced through different methods as brought for further study in this review.

Cite this article as:

Ziarani Mohammadi Ghodsi *, Mohajer Fatemeh and Mali N. Suraj , The Molecular Diversity of 1,8-diaminonaphthalene in Organic Chemistry, Combinatorial Chemistry & High Throughput Screening 2021; 24 (10) . https://dx.doi.org/10.2174/1386207323666201110144014