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Combinatorial Chemistry & High Throughput Screening

Editor-in-Chief

ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

General Review Article

The Molecular Diversity of 1,8-diaminonaphthalene in Organic Chemistry

Author(s): Ghodsi Mohammadi Ziarani*, Fatemeh Mohajer and Suraj N. Mali

Volume 24 , Issue 10 , 2021

Published on: 10 November, 2020

Page: [1702 - 1713] Pages: 12

DOI: 10.2174/1386207323666201110144014

Price: $65

Abstract

Background: 1,8-diaminonaphthalen (1,8-DAN) with special organic structure was applied in organic synthesis to provide efficient complex scaffolds, through the two or fourcomponent fashion. This review highlights its recent application in organic reactions under different conditions and heterogynous catalysts to produce various molecules, which were used as medicines, sensors, and dyes.

Objective: 1,8-diaminonaphthalene (1,8-DAN) is a bicyclic compound with two amino groups which has received much attention in organic chemistry due to their medicinal activities such as antifungal, antimicrobial, antiulcer, antitumor, oxidation dyestuff, hair color, fluorescent, and chemo-sensors. In continuation of our studies, herin, recent application of 1,8-DAN in organic synthesis was reviewed.

Conclusion: In conclusion, the application of 1,8-DAN 1 in different reactions was reviewd through the various conditions to yield the target compounds with high medicinal activities, and potential for sensitive detection of different ions. The target compounds including 1,8-DAN 1 with various structures were provided such as perimidines, perimidinones, aminonaphthalenes which were produced through different methods as brought for further study in this review.

Keywords: 1, 8-diaminonaphthalene (1, 8-DAN), perimidines, dihydro perimidines, perimidones, Different amino scaffold, molecular diversity.


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