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Current Drug Research Reviews

Editor-in-Chief

ISSN (Print): 2589-9775
ISSN (Online): 2589-9783

Review Article

The Role of Signaling Pathway in the Biological Cause of Rheumatoid Arthritis

Author(s): Rakesh Kumar Chauhan, Pramod Kumar Sharma and Shikha Srivastava*

Volume 13, Issue 2, 2021

Published on: 09 November, 2020

Page: [130 - 139] Pages: 10

DOI: 10.2174/2589977512999201109215004

Price: $65

Abstract

Rheumatoid arthritis not only affects synovial joints but also many other sites including heart, blood vessels, and skins. It is more common in females than in males. The exact cause of rheumatoid arthritis is not well established, but the hypothesis reported in the literature is that in the development stage of the disease, both genetics and environmental factors can play an inciting role. Along with these factors, the alteration in the normal physiology of enzymatic action acts as a trigger to develop this condition. Numerous signaling pathways in the pathogenesis of Rheumatoid Arthritis involve activation of mitogen-activated protein kinase, kinases Janus family, P-38 Mitogen- Activated Protein Kinase and Nuclear Factor-kappa B. Interleukin-1, is a proinflammatory cytokine that plays an important role in inflammation in RA. These are also associated with an increase in neutrophil, macrophage and lymphocytic chemotaxis, mast cell degranulation, activation, maturation and survival of T-cells and B-cells activated. These signaling pathways also show that p38α downregulation in myeloid cells exacerbates the severity of symptoms of arthritis. Thus, the present review carters about the detail of different signaling pathways and their role in rheumatoid arthritis.

Keywords: Rheumatoid arthritis, interleukin, JAK-STAT, MAP, signaling pathway, P-38 MAPK.

Graphical Abstract
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