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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Research Article

Ag(I)-promoted Decarboxylative Annulation of α-Oxocarboxylic Acids with (E)-3-(2-aminophenyl)-1-Phenylprop-2-en-1-ones Toward 3,4- Functionalized Quinolines

Author(s): Xiaodong Fan, Chang Wang and Jiang Cheng*

Volume 18 , Issue 10 , 2021

Published on: 06 November, 2020

Page: [777 - 782] Pages: 6

DOI: 10.2174/1570178617999201106141315

Price: $65

Abstract

An efficient Ag-promoted decarboxylative cyclization of α-oxocarboxylic acids with (E)-3- (2-aminophenyl)-1-phenylprop-2-en-1-ones has been developed to afford a series of functionalized quinolines in moderate to good yields. This method was compatible with a variety of functional groups and provided an attractive method toward phenyl(2-phenylquinolin-3-yl)methanones.

Keywords: α-oxocarboxylic acids, (E)-3-(2-aminophenyl)-1-phenylprop-2-en-1-ones, Ag-promoted, decarboxylative cyclization, intramolecular 6π-electrocyclization, quinolines derivatives.

Graphical Abstract

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