Ag(I)-promoted Decarboxylative Annulation of α-Oxocarboxylic Acids with (E)-3-(2-aminophenyl)-1-Phenylprop-2-en-1-ones Toward 3,4- Functionalized Quinolines

Title:Ag(I)-promoted Decarboxylative Annulation of α-Oxocarboxylic Acids with (E)-3-(2-aminophenyl)-1-Phenylprop-2-en-1-ones Toward 3,4- Functionalized Quinolines

Volume: 18 Issue: 10

Author(s): Xiaodong Fan, Chang Wang and Jiang Cheng*

Affiliation:

• School of Petrochemical Engineering, and Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, Changzhou University, Changzhou 213164,China

Keywords: α-oxocarboxylic acids, (E)-3-(2-aminophenyl)-1-phenylprop-2-en-1-ones, Ag-promoted, decarboxylative cyclization, intramolecular 6π-electrocyclization, quinolines derivatives.

Abstract: An efficient Ag-promoted decarboxylative cyclization of α-oxocarboxylic acids with (E)-3- (2-aminophenyl)-1-phenylprop-2-en-1-ones has been developed to afford a series of functionalized quinolines in moderate to good yields. This method was compatible with a variety of functional groups and provided an attractive method toward phenyl(2-phenylquinolin-3-yl)methanones.

Cite this article as:

Fan Xiaodong , Wang Chang and Cheng Jiang *, Ag(I)-promoted Decarboxylative Annulation of α-Oxocarboxylic Acids with (E)-3-(2-aminophenyl)-1-Phenylprop-2-en-1-ones Toward 3,4- Functionalized Quinolines, Letters in Organic Chemistry 2021; 18 (10) . https://dx.doi.org/10.2174/1570178617999201106141315