Quinone-Based Drugs: An Important Class of Molecules in Medicinal Chemistry

Title:Quinone-Based Drugs: An Important Class of Molecules in Medicinal Chemistry

Volume: 17 Issue: 10

Author(s): Vitor F. Ferreira*, Alcione S. de Carvalho, Patricia G. Ferreira, Carolina G.S. Lima and Fernando de C. da Silva

Affiliation:

• Universidade Federal Fluminense, Instituto de Quimica, Departamento de Quimica Organica, Campus do Valonguinho, Niterói, 24020-150, RJ,Brazil

Keywords: Atovaquone, buparvaquone, parvaquone, mitomycins, doxorubicin, valrubicin, mitoxantrone.

Abstract:

Background: Several quinones are on the pharmaceutical market as drugs for the treatment of several diseases.

Objective: The aim of this review was to provide an overview of the quinones that have become drugs for several therapeutic applications.

Methods: We have comprehensively and critically discussed all the information available in the literature about quinone-based drugs.

Results: In this review, the various aspects of the chemistry and biochemistry of these drugs are highlighted, including their repositioning, drug combination and their new uses.

Conclusion: A number of studies related to quinone drugs for different pharmaceutical uses show that the interest in new applications is still increasing in recent years.

Cite this article as:

Ferreira F. Vitor *, de Carvalho S. Alcione , Ferreira G. Patricia, Lima G.S. Carolina and de C. da Silva Fernando , Quinone-Based Drugs: An Important Class of Molecules in Medicinal Chemistry, Medicinal Chemistry 2021; 17(10) . https://dx.doi.org/10.2174/1573406416666201106104756