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Medicinal Chemistry


ISSN (Print): 1573-4064
ISSN (Online): 1875-6638

Review Article (Mini-Review)

Quinone-Based Drugs: An Important Class of Molecules in Medicinal Chemistry

Author(s): Vitor F. Ferreira*, Alcione S. de Carvalho, Patricia G. Ferreira, Carolina G.S. Lima and Fernando de C. da Silva

Volume 17 , Issue 10 , 2021

Published on: 05 November, 2020

Page: [1073 - 1085] Pages: 13

DOI: 10.2174/1573406416666201106104756

Price: $65


Background: Several quinones are on the pharmaceutical market as drugs for the treatment of several diseases.

Objective: The aim of this review was to provide an overview of the quinones that have become drugs for several therapeutic applications.

Methods: We have comprehensively and critically discussed all the information available in the literature about quinone-based drugs.

Results: In this review, the various aspects of the chemistry and biochemistry of these drugs are highlighted, including their repositioning, drug combination and their new uses.

Conclusion: A number of studies related to quinone drugs for different pharmaceutical uses show that the interest in new applications is still increasing in recent years.

Keywords: Atovaquone, buparvaquone, parvaquone, mitomycins, doxorubicin, valrubicin, mitoxantrone.

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