Generic placeholder image

Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Review Article

Marine Bioactive Peptides in Supplements and Functional Foods - A Commercial Perspective

Author(s): Ragnhild Dragøy Whitaker*, Themis Altintzoglou, Kjersti Lian and Estefania Noriega Fernandez

Volume 27, Issue 11, 2021

Published on: 05 November, 2020

Page: [1353 - 1364] Pages: 12

DOI: 10.2174/1381612824999201105164000

open access plus

Abstract

Many bioactive peptides have been described from marine sources and much marine biomass is still not explored or utilized in products. Marine peptides can be developed into a variety of products, and there is a significant interest in the use of bioactive peptides from marine sources for nutraceuticals or functional foods. We present here a mini-review collecting the knowledge about the value chain of bioactive peptides from marine sources used in nutraceuticals and functional foods. Many reports describe bioactive peptides from marine sources, but in order to make these available to the consumers in commercial products, it is important to connect the bioactivities associated with these peptides to commercial opportunities and possibilities. In this mini-review, we present challenges and opportunities for the commercial use of bioactive peptides in nutraceuticals and functional food products. We start the paper by introducing approaches for isolation and identification of bioactive peptides and candidates for functional foods. We further discuss market-driven innovation targeted to ensure that isolated peptides and suggested products are marketable and acceptable by targeted consumers. To increase the commercial potential and ensure the sustainability of the identified bioactive peptides and products, we discuss scalability, regulatory frameworks, production possibilities and the shift towards greener technologies. Finally, we discuss some commercial products from marine peptides within the functional food market. We discuss the placement of these products in the larger picture of the commercial sphere of functional food products from bioactive peptides.

Keywords: Market, demonstration, bioactive peptides, marine, side streams, scale-up, commercialization.

[1]
Jamnik P, Istenič K, Koštomaj T, et al. Bioactivity of Cod and Chicken Protein Hydrolysates before and after in vitro Gastrointestinal Digestion. Food Technol Biotechnol 2017; 55(3): 360-7.
[http://dx.doi.org/10.17113/ftb.55.03.17.5117] [PMID: 29089849]
[2]
Wubshet SG. Bioanalytical aspects in enzymatic protein hydrolysis of by-products. Proteins: sustainable source, processing and applications. Academic Press 2019; 225-58.
[http://dx.doi.org/10.1016/B978-0-12-816695-6.00008-8]
[3]
Vang B. CHAPTER 17 Nofima:Peptide Recovery and Commercialization by Enzymatic Hydrolysis of Marine BiomassBiocatalysis: An Industrial Perspective. In: The Royal Society of Chemistry. 2018; pp. (): 459-76.
[4]
Giordano D. Chapter Five - Biotechnological Applications of Bioactive Peptides From Marine Sources.Advances in Microbial Physiology.Academic Press. 2018; pp. pp 171-220.
[5]
Altmann K-H. Drugs from the oceans: marine natural products as leads for drug discovery. Chimia (Aarau) 2017; 71(10): 646-52.
[http://dx.doi.org/10.2533/chimia.2017.646] [PMID: 29070409]
[6]
Bhatt S, Lee J, Deutsch J, Ayaz H. From food waste to value-added surplus products (VASP): Consumer acceptance of a novel food product category. J Consum Behav 2018; 17(1): 57-63.
[http://dx.doi.org/10.1002/cb.1689]
[7]
Nova P, Pimenta-Martins A, Laranjeira Silva J, Silva AM, Gomes AM, Freitas AC. Health benefits and bioavailability of marine resources components that contribute to health - what’s new? Crit Rev Food Sci Nutr 2020; 60(21): 3680-92.
[http://dx.doi.org/10.1080/10408398.2019.1704681] [PMID: 31920109]
[8]
Hansen C, Nash RDM, Drinkwater KF, Hjollo SS. Management scenarios under climate change - a study of the nordic and barents seas. Front Mar Sci 2019; 6(668).
[http://dx.doi.org/10.3389/fmars.2019.00668]
[9]
Stincone P, Brandelli A. Marine bacteria as source of antimicrobial compounds. Crit Rev Biotechnol 2020; 40(3): 306-19.
[http://dx.doi.org/10.1080/07388551.2019.1710457] [PMID: 31992085]
[10]
Suleria HAR, Gobe G, Masci P, Osborne SA. Marine bioactive compounds and health promoting perspectives; innovation pathways for drug discovery. Trends Food Sci Technol 2016; 50: 44-55.
[http://dx.doi.org/10.1016/j.tifs.2016.01.019]
[11]
Jo C, Khan MI, Iqbal I, Khan FF. Marine bioactive peptides: Types, structures, and physiological functions. Food Rev Int 2017; 33(1): 44-61.
[http://dx.doi.org/10.1080/87559129.2015.1137311]
[12]
Freitas AC, Pereira L, Rodrigues D. Marine Functional Foods. Springer Handbook of Marine Biotechnology.Berlin, Heidelberg: Springer Berlin Heidelberg. 2015; pp. pp 969-994.
[http://dx.doi.org/10.1007/978-3-642-53971-8_42]
[13]
Troy DJ, Tiwari BK, Hayes M, et al. Marine Functional Foods Research Initiative (NutraMara).MFFRI/07/01.Marine Institute. 2017.
[14]
Suleria HAR, Osborne S, Masci P, Gobe G. Marine-based nutraceuticals: an innovative trend in the food and supplement industries. Mar Drugs 2015; 13(10): 6336-51.
[http://dx.doi.org/10.3390/md13106336] [PMID: 26473889]
[15]
Vaz BS, Moreira JB, Morais MG, Costa JAV. Microalgae as a new source of bioactive compounds in food supplements. Curr Opin Food Sci 2016; 7: 73-7.
[http://dx.doi.org/10.1016/j.cofs.2015.12.006]
[16]
Wang CH, Doan CT, Nguyen AD, Wang SL. Reclamation of fishery processing waste: a mini-review. Molecules 2019; 24(12): E2234.
[http://dx.doi.org/10.3390/molecules24122234] [PMID: 31207992]
[17]
Ghanbari R. Review on the bioactive peptides from marine sources: indication for health effects. Int J Pept Res Ther 2019; 25(3): 1187-99.
[http://dx.doi.org/10.1007/s10989-018-9766-x]
[18]
Thangaraj S, Bragadeeswaran S, Gokula V. Sea anemones as potential source for bioactive metabolites. Int J Pept Res Ther 2019; 25(2): 591-604.
[http://dx.doi.org/10.1007/s10989-018-9705-x]
[19]
Aspevik T, Oterhals Å, Rønning SB, et al. Valorization of proteins from co- and by-products from the fish and meat industry. Top Curr Chem (Cham) 2017; 375(3): 53.
[http://dx.doi.org/10.1007/s41061-017-0143-6] [PMID: 28466455]
[20]
Commission E. Blue Bioeconomy forum Roadmap for the blue bioeconomy. In: Publications Office of the European Union. 2019.
[21]
Youssef FS, Ashour ML, Singab ANB, Wink M. A Comprehensive Review of Bioactive Peptides from Marine Fungi and Their Biological Significance. Mar Drugs 2019; 17(10): 559.
[http://dx.doi.org/10.3390/md17100559] [PMID: 31569458]
[22]
Calado R, Leal MC, Gaspar H, et al. How to succeed in marketing marine natural products for nutraceutical, pharmaceutical and cosmeceutical markets. Grand challenges in marine biotechnology Cham: Springer International Publishing . Springer International Publishing 2018; pp. pp 317-403.
[http://dx.doi.org/10.1007/978-3-319-69075-9_9]
[23]
Cheung RCF, Ng TB, Wong JH. Marine peptides: bioactivities and applications. Mar Drugs 2015; 13(7): 4006-43.
[http://dx.doi.org/10.3390/md13074006] [PMID: 26132844]
[24]
Odeleye T, White WL, Lu J. Extraction techniques and potential health benefits of bioactive compounds from marine molluscs: a review. Food Funct 2019; 10(5): 2278-89.
[http://dx.doi.org/10.1039/C9FO00172G] [PMID: 30968919]
[25]
Qin Y. 6 - Applications of bioactive seaweed substances in functional food products. Bioactive seaweeds for food applications Academic Press. 2018; pp. pp 111-134.
[http://dx.doi.org/10.1016/B978-0-12-813312-5.00006-6]
[26]
Harnedy PA, FitzGerald RJ. Bioactive peptides from marine processing waste and shellfish: A review. J Funct Foods 2012; 4(1): 6-24.
[http://dx.doi.org/10.1016/j.jff.2011.09.001]
[27]
Le Gouic AV, Harnedy PA, FitzGerald RJ. Bioactive peptides from fish protein by-products. Bioactive molecules in foodCham: Springer International Publishing. 2018; pp. pp. 1-35.
[28]
Hayes M, Bastiaens L, Gouviea L. Microalgal bioactive compounds including protein, peptides, and pigments: applications, opportunities, and challenges during biorefinery processes. Novel Proteins for Food, Pharmaceuticals and Agriculture: Sources, Applications and Advances. 2018; pp. 239-55.
[http://dx.doi.org/10.1002/9781119385332.ch12]
[29]
Hayes M, Tiwari BK. Bioactive carbohydrates and Peptides in Foods: An Overview of Sources, Downstream Processing Steps and Associated Bioactivities. Int J Mol Sci 2015; 16(9): 22485-508.
[http://dx.doi.org/10.3390/ijms160922485] [PMID: 26393573]
[30]
EU. Regulation (ec) no 1069/2009 of the european parliament and of the council of 21 October 2009 on animal byproductsEUR- Lex. 2009.
[31]
EU, Regulation (EU) 2015/2283 of the European Parliament and of the Council of 25 November 2015 on novel foods. EUR-Lex 2015.
[32]
Sila A, Bougatef A. Antioxidant peptides from marine by-products: Isolation, identification and application in food systems. A review. J Funct Foods 2016; 21: 10-26.
[http://dx.doi.org/10.1016/j.jff.2015.11.007]
[33]
Hellsmark H, Frishammar J, Soderholm P, Ylinenpää H. The role of pilot and demonstration plants in technology development and innovation policy. Res Policy 2016; 45(9): 1743-61.
[http://dx.doi.org/10.1016/j.respol.2016.05.005]
[34]
Petrova I, Tolstorebrov I, Eikevik TM. Production of fish protein hydrolysates step by step: technological aspects, equipment used, major energy costs and methods of their minimizing. Int Aquatic Research 2018; 10(3): 223-41.
[http://dx.doi.org/10.1007/s40071-018-0207-4]
[35]
Altintzoglou T, Honkanen P, Whitaker RD. Attitudes towards sustainable products are influenced by involvement in food waste reduction. J Clean Prod 2020.
[36]
Al Khawli F, Ferrer E, Berrada H, et al. Innovative green technologies of intensification for valorization of seafood and their by-products. Mar Drugs 2019; 17(12): E689.
[http://dx.doi.org/10.3390/md17120689] [PMID: 31817754]
[37]
Fletcher AC, Bourne PE. Ten simple rules to commercialize scientific research. PLOS Comput Biol 2012; 8(9): e1002712.
[http://dx.doi.org/10.1371/journal.pcbi.1002712] [PMID: 23028299]
[38]
Falanga A, Lombardi L, Franci G, et al. Marine antimicrobial peptides: nature provides templates for the design of novel compounds against pathogenic bacteria. Int J Mol Sci 2016; 17(5): 785.
[http://dx.doi.org/10.3390/ijms17050785] [PMID: 27213366]
[39]
Adnan M, Alshammari E, Patel M, Amir Ashraf S, Khan S, Hadi S. Significance and potential of marine microbial natural bioactive compounds against biofilms/biofouling: necessity for green chemistry. PeerJ 2018; 6: e5049-9.
[http://dx.doi.org/10.7717/peerj.5049] [PMID: 29967730]
[40]
Ingebrigtsen RA, Hansen E, Andersen JH, Eilertsen HC. Field sampling marine plankton for biodiscovery. Sci Rep 2017; 7(1): 15863.
[http://dx.doi.org/10.1038/s41598-017-15980-8] [PMID: 29158560]
[41]
Wangchuk P, Loukas A. Techniques and technologies for the biodiscovery of novel small molecule drug lead compounds from natural products.Natural Products and Drug Discovery Elsevier. 2018; pp. pp.435-65.
[http://dx.doi.org/10.1016/B978-0-08-102081-4.00016-2]
[42]
Agyei D, Danquah MK. Industrial-scale manufacturing of pharmaceutical-grade bioactive peptides. Biotechnol Adv 2011; 29(3): 272-7.
[http://dx.doi.org/10.1016/j.biotechadv.2011.01.001] [PMID: 21238564]
[43]
Fujimura Y, Kawano C, Maeda-Murayama A, et al. A chemometrics-driven strategy for the bioactivity evaluation of complex multicomponent systems and the effective selection of bioactivity-predictive chemical combinations. Sci Rep 2017; 7(1): 2257.
[http://dx.doi.org/10.1038/s41598-017-02499-1] [PMID: 28536476]
[44]
Van Der Ven C, Muresan S, Gruppen H, De Bont DB, Merck KB, Voragen AG. FTIR spectra of whey and casein hydrolysates in relation to their functional properties. J Agric Food Chem 2002; 50(24): 6943-50.
[http://dx.doi.org/10.1021/jf020387k] [PMID: 12428941]
[45]
Hajfathalian M, Ghelichi S, García-Moreno PJ, Moltke Sørensen AD, Jacobsen C. Peptides: Production, bioactivity, functionality, and applications. Crit Rev Food Sci Nutr 2018; 58(18): 3097-129.
[http://dx.doi.org/10.1080/10408398.2017.1352564] [PMID: 29020461]
[46]
Bechaux J, Gatellier P, Le Page JF, Drillet Y, Sante-Lhoutellier V. A comprehensive review of bioactive peptides obtained from animal byproducts and their applications. Food Funct 2019; 10(10): 6244-66.
[http://dx.doi.org/10.1039/C9FO01546A] [PMID: 31577308]
[47]
Tu M, Cheng S, Lu W, Du M. Advancement and prospects of bioinformatics analysis for studying bioactive peptides from food-derived protein: Sequence, structure, and functions. Trends Analyt Chem 2018; 105: 7-17.
[http://dx.doi.org/10.1016/j.trac.2018.04.005]
[48]
Acquah C, Chan YW, Pan S, Agyei D, Udenigwe CC. Structure-informed separation of bioactive peptides. J Food Biochem 2019; 43(1): e12765.
[http://dx.doi.org/10.1111/jfbc.12765] [PMID: 31353493]
[49]
Carrasco-Castilla J, Hernandez-Alvarez AJ, Jimenez-Martinez C. Use of proteomics and Peptidomics Methods in Food Bioactive Peptide Science and Engineering. Food Eng Rev 2012; 4(4): 224-43.
[http://dx.doi.org/10.1007/s12393-012-9058-8]
[50]
Donner M, Gohier R, de Vries H. A new circular business model typology for creating value from agro-waste. Sci Total Environ 2020; 716: 137065.
[http://dx.doi.org/10.1016/j.scitotenv.2020.137065] [PMID: 32044489]
[51]
EMF. Cities and Circular Economy for Food. Foundation EM, Ed. 2019.
[52]
Hofenk D, Bloemer Josee, Birgelen M, Semeijn J. How and when retailers’ sustainability efforts translate into positive consumer responses: the interplay between personal and social factors. J Bus Ethics 2019; 156(2): 473-92.
[http://dx.doi.org/10.1007/s10551-017-3616-1]
[53]
Olafsen T, Winther U, Olsen Y, Skjermo J. Value created from productive oceans in 2050, 2016.RNSoSaLDatNAoTS (NTVA), Editor. 2016.
[54]
Pandal N. Nutraceuticals; Global Markets. 2017.
[55]
Insights CM. Bioactive Protein & Peptides Market Size, Trends, Shares, Insights and Forecast - 2027Coherent Market Insights. 2020.
[56]
Sidali KL, Spiller A, von Meyer-Hofer M. Consumer expectations regarding sustainable food: insights from developed and emerging markets. Int Food Agribus Manag Rev 2016; 19(3): 1-30.
[57]
Miller LMS, Cassady DL. The effects of nutrition knowledge on food label use. A review of the literature. Appetite 2015; 92: 207-16.
[http://dx.doi.org/10.1016/j.appet.2015.05.029] [PMID: 26025086]
[58]
Chalamaiah M, Ulug SK, Hong H, Wu J. Regulatory requirements of bioactive peptides (protein hydrolysates) from food proteins. J Funct Foods 2019; 58: 123-9.
[http://dx.doi.org/10.1016/j.jff.2019.04.050]
[59]
Holle M. The protection of proprietary data in novel foods - how to make it work. Eur Food Feed Law Rev 2014; 9(5)
[61]
Cheftel JC. Food and nutrition labelling in the European Union. Food Chem 2005; 93(3): 531-50.
[http://dx.doi.org/10.1016/j.foodchem.2004.11.041]
[62]
Tavano OL. Protein hydrolysis using proteases: An important tool for food biotechnology. J Mol Catal, B Enzym 2013; 90: 1-11.
[http://dx.doi.org/10.1016/j.molcatb.2013.01.011]
[63]
Xu Q, Hong H, Yu W, Jiang X, Yan X, Wu J. Sodium chloride suppresses the bitterness of protein hydrolysates by decreasing hydrophobic interactions. J Food Sci 2019; 84(1): 86-91.
[http://dx.doi.org/10.1111/1750-3841.14419] [PMID: 30561810]
[64]
Nguyen E, Kim YSB, Martin-Gonzalez MFS, Jones W. Impact of microwave-assisted enzymatic hydrolysis on functional and antioxidant properties of rainbow trout Oncorhynchus mykiss by-products. Fish Sci 2017; 83(2): 317-31.
[http://dx.doi.org/10.1007/s12562-017-1067-3]
[65]
Musa A, Gasmalla MAA, Ma H, et al. A new continuous system of enzymatic hydrolysis coupled with membrane separation for isolation of peptides with angiotensin I converting enzyme inhibitory capacity from defatted corn germ protein. Food Funct 2020; 11(1): 1146-54.
[http://dx.doi.org/10.1039/C9FO01980D] [PMID: 31830159]
[66]
Sewczyk T, Hoog Antink M, Maas M, Kroll S, Beutel S. Flow rate dependent continuous hydrolysis of protein isolates. AMB Express 2018; 8(1): 18-8.
[http://dx.doi.org/10.1186/s13568-018-0548-9] [PMID: 29429128]
[67]
Xiao P, Chen Y, Chen J, Huang H. Nutritional evaluation, characterization and antioxidant activity of radix isatidis protein hydrolysates under simulated gastrointestinal digestion. J Food Nutr Res 2014; 2(11): 831-8.
[http://dx.doi.org/10.12691/jfnr-2-11-12]
[68]
Rutherfurd SM. Methodology for determining degree of hydrolysis of proteins in Hydrolysates: a review. J AOAC Int 2010; 93(5): 1515-22.
[http://dx.doi.org/10.1093/jaoac/93.5.1515] [PMID: 21140664]
[69]
Kristoffersen KA, Liland KH, Böcker U, et al. FTIR-based hierarchical modeling for prediction of average molecular weights of protein hydrolysates. Talanta 2019; 205: 120084.
[http://dx.doi.org/10.1016/j.talanta.2019.06.084] [PMID: 31450429]
[70]
Karatzas YKNCANVPVKAG. Application of innovative technologies for improved food quality and safety.BioMed Research International. 2016.
[71]
Paulsen Thoresen P, Garcia A, Vaka R. Potential of innovative pre-treatment technologies for the revalorisation of rest raw materials from the chicken industry through enzymatic hydrolysis. Innov Food Sci Emerg Technol 2020; 2020 Submitted.
[72]
Zhang Z-H, Wang L-H, Zeng X-A, Han Z. Non-thermal technologies and its current and future application in the food industry: a review. Int J Food Sci Technol 2019; 54(1): 1-13.
[http://dx.doi.org/10.1111/ijfs.13903]
[73]
Wen L, Zhang Z, Sun DW, Sivagnanam SP, Tiwari BK. Combination of emerging technologies for the extraction of bioactive compounds. Crit Rev Food Sci Nutr 2019; 1-16.
[http://dx.doi.org/10.1080/10408398.2019.1602823] [PMID: 30990060]
[74]
Zhao W, Yang R. Pulsed electric fields for inactivation of endogenous enzymes in foods.Handbook of Electroporation Cham: Springer International Publishing. 2017; pp. pp 2239-51.
[http://dx.doi.org/10.1007/978-3-319-32886-7_130]
[75]
O’Donnell CP, Tiwari BK, Bourke P. Effect of ultrasonic processing on food enzymes of industrial importance. Trends Food Sci Technol 2010; 21(7): 358-67.
[http://dx.doi.org/10.1016/j.tifs.2010.04.007]
[76]
Hu W, Zhou L, Xu Z, Zhang Y, Liao X. Enzyme inactivation in food processing using high pressure carbon dioxide technology. Crit Rev Food Sci Nutr 2013; 53(2): 145-61.
[http://dx.doi.org/10.1080/10408398.2010.526258] [PMID: 23072530]
[77]
Chizoba Ekezie F-G, Cheng J-H, Sun D-W. Effects of nonthermal food processing technologies on food allergens: A review of recent research advances. Trends Food Sci Technol 2018; 74: 12-25.
[http://dx.doi.org/10.1016/j.tifs.2018.01.007]
[78]
Dong X, Wang J, Raghavan V. Critical reviews and recent advances of novel non-thermal processing techniques on the modification of food allergens. Crit Rev Food Sci Nutr 2020; 61(2): 196-210.
[http://dx.doi.org/10.1080/10408398.2020.1722942] [PMID: 32048519]
[79]
Bloemhof JM, Jack GAJ van der Vorst, Marko Bastl, Allaoui H. Sustainability assessment of food chain logistics. International Journal of Logistics Research and Applications 2015; 18(2): 101-17.
[http://dx.doi.org/10.1080/13675567.2015.1015508]
[80]
Kayode CA. Chapter Thirteen - Scale-Up in Reactor Design Modeling of Chemical Kinetics and Reactor DesignWoburn: Gulf Professional Publishing. Woburn: Gulf Professional Publishing 2001; pp. pp 1034-81.
[81]
Welty JR. Fundamentals of momentum, heat and mass transfer. Willey 2013.
[82]
Hammaini A, González F, Ballester A, Blázquez ML, Muñoz JA. Biosorption of heavy metals by activated sludge and their desorption characteristics. J Environ Manage 2007; 84(4): 419-26.
[http://dx.doi.org/10.1016/j.jenvman.2006.06.015] [PMID: 16979281]
[83]
Bakkaloglu IB. T J Evison, L M Holland, FS Hancock, I C. Screening of various types biomass for removal and recovery of heavy metals (Zn, Cu, Ni) by biosorption, sedimentation and desorption. Water Sci Technol 1998; 38(6): 269-77.
[http://dx.doi.org/10.2166/wst.1998.0261]
[84]
Poulsen NA, Eskildsen CE, Akkerman M. Predicting hydrolysis of whey protein by mid-infrared spectroscopy. Int Dairy J 2016; 61: 44-50.
[http://dx.doi.org/10.1016/j.idairyj.2016.04.002]
[85]
Mujumdar AS, Law CL. Drying technology: trends and applications in postharvest processing. Food Bioprocess Technol 2010; 3(6): 843-52.
[http://dx.doi.org/10.1007/s11947-010-0353-1]
[86]
Raghavi LM, Moses JA, Anandharamakrishnan C. Refractance window drying of foods: A review. J Food Eng 2018; 222: 267-75.
[http://dx.doi.org/10.1016/j.jfoodeng.2017.11.032]
[87]
Macdonald RJ, Middlewood PG, MacManus RL. Development and characterisation of a vacuum flash evaporator for concentrating a heat sensitive aqueous peptide stream. Desalination 2008; 218(1): 238-47.
[http://dx.doi.org/10.1016/j.desal.2007.02.019]
[88]
Patel SM, Pikal MJ. Emerging freeze-drying process development and scale-up issues. AAPS PharmSciTech 2011; 12(1): 372-8.
[http://dx.doi.org/10.1208/s12249-011-9599-9] [PMID: 21347620]
[89]
Frishammar J, Palage K, Hellsmark H, Soderholm P. The role of pilot and demonstration plants in technological development: synthesis and directions for future research. Technol Anal Strateg Manage 2015; 27(1): 1-18.
[http://dx.doi.org/10.1080/09537325.2014.943715]
[90]
Pilots4U 2020. Available from: https://biopilots4u.eu/
[91]
Kim SK. Marine proteins and Peptides: Biological Activities and ApplicationsWiley. 2013.
[http://dx.doi.org/10.1002/9781118375082]
[92]
Gildberg A. Angiotensin I-converting enzyme inhibitory activity in a hydrolysate of proteins from Northern shrimp (Pandalus borealis) and identification of two novel inhibitory tri-peptides. Process Biochem 2011; 46: 2205-9.
[http://dx.doi.org/10.1016/j.procbio.2011.08.003]
[93]
Wang G, Li X, Wang Z. APD3: the antimicrobial peptide database as a tool for research and education. Nucleic Acids Res 2016; 44(D1): D1087-93.
[http://dx.doi.org/10.1093/nar/gkv1278] [PMID: 26602694]
[94]
Minkiewicz P, Dziuba J, Iwaniak A, Dziuba M, Darewicz M. BIOPEP database and other programs for processing bioactive peptide sequences. J AOAC Int 2008; 91(4): 965-80.
[http://dx.doi.org/10.1093/jaoac/91.4.965] [PMID: 18727559]
[95]
Waghu FH, Barai RS, Gurung P, Idicula-Thomas S. CAMPR3: a database on sequences, structures and signatures of antimicrobial peptides. Nucleic Acids Res 2016; 44(D1): D1094-7.
[http://dx.doi.org/10.1093/nar/gkv1051] [PMID: 26467475]
[96]
Shtatland T, Guettler D, Kossodo M, Pivovarov M, Weissleder R. PepBank--a database of peptides based on sequence text mining and public peptide data sources. BMC Bioinformatics 2007; 8(1): 280.
[http://dx.doi.org/10.1186/1471-2105-8-280] [PMID: 17678535]
[97]
Shen Y, Maupetit J, Derreumaux P, Tufféry P. Improved PEP-FOLD approach for peptide and miniprotein structure prediction. J Chem Theory Comput 2014; 10(10): 4745-58.
[http://dx.doi.org/10.1021/ct500592m] [PMID: 26588162]
[98]
Gasteiger E. Protein Identification and Analysis Tools on the ExPASy Server. In: The Proteomics Protocols Handboo, JM Walker, EditorHumana Press. 2005; pp. pp. 571-607.
[99]
Mooney C, Haslam NJ, Holton TA, Pollastri G, Shields DC. PeptideLocator: prediction of bioactive peptides in protein sequences. Bioinformatics 2013; 29(9): 1120-6.
[http://dx.doi.org/10.1093/bioinformatics/btt103] [PMID: 23505299]
[100]
Mooney C, Haslam NJ, Pollastri G, Shields DC. Towards the improved discovery and design of functional peptides: common features of diverse classes permit generalized prediction of bioactivity. PLoS One 2012; 7(10): e45012.
[http://dx.doi.org/10.1371/journal.pone.0045012] [PMID: 23056189]
[101]
Manguy J, Jehl P, Dillon ET, Davey NE, Shields DC, Holton TA. Peptigram: a web-based application for peptidomics data visualization. J Proteome Res 2017; 16(2): 712-9.
[http://dx.doi.org/10.1021/acs.jproteome.6b00751] [PMID: 27997202]
[102]
Gupta S, Kapoor P, Chaudhary K, Gautam A, Kumar R, Raghava GP. Open source drug discovery consortium. In silico approach for predicting toxicity of peptides and proteins. PLoS One 2013; 8(9): e73957.
[http://dx.doi.org/10.1371/journal.pone.0073957] [PMID: 24058508]
[103]
Pundir S, Michele Magrane, Maria J Martin, Claire O’Donovan. Searching and navigating UniProt databases. Current protocols in bioinformatics 2015.
[http://dx.doi.org/10.1002/0471250953.bi0127s50]
[104]
Vázquez J, Nogueira M, Menduíña A. Tailor-Made Process to Recover High Added Value Compounds from Fishery By-Products. 2019; 91-140.
[http://dx.doi.org/10.1201/9780429325007-4]
[105]
Silva TH, Moreira-Silva J, Marques AL, Domingues A, Bayon Y, Reis RL. Marine origin collagens and its potential applications. Mar Drugs 2014; 12(12): 5881-901.
[http://dx.doi.org/10.3390/md12125881] [PMID: 25490254]
[106]
Turck D, Bresson JL, Burlingame B, et al. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA). Safety of shrimp peptide concentrate as a novel food pursuant to Regulation (EU) 2015/2283. EFSA J 2018; 16(5): e05267.
[PMID: 32625904]
[107]
Sato M, Hosokawa T, Yamaguchi T, et al. Angiotensin I-converting enzyme inhibitory peptides derived from wakame (Undaria pinnatifida) and their antihypertensive effect in spontaneously hypertensive rats. J Agric Food Chem 2002; 50(21): 6245-52.
[http://dx.doi.org/10.1021/jf020482t] [PMID: 12358510]
[108]
Guillerminet F, Beaupied H, Fabien-Soulé V, et al. Hydrolyzed collagen improves bone metabolism and biomechanical parameters in ovariectomized mice: an in vitro and in vivo study. Bone 2010; 46(3): 827-34.
[http://dx.doi.org/10.1016/j.bone.2009.10.035] [PMID: 19895915]
[109]
Boutin Y, Couture P, Paradis ME, Lamarche B. Immunological effect of fish protein supplementation on healthy adults. J Nat Prod 2012; 5: 37-44.
[110]
Fitzgerald AJ, Rai PS, Marchbank T, et al. Reparative properties of a commercial fish protein hydrolysate preparation. Gut 2005; 54(6): 775-81.
[http://dx.doi.org/10.1136/gut.2004.060608] [PMID: 15888784]
[111]
Dermatest, "Seagarden Marine Collagen Peptide Powder (3 kDa)" - Dermatological expertise on an eight-week lasting clinical-dermatological application test with hydration determination using a corneometer, Dermatest, Editor 2017, Dermatest® GmbH I Engelstrasse 37 I 48143 Münste 2017. Available from: https://cdn.shopify.com/s/files/1/0009/6616/4524/files/Expertise_Seagarden_final_07_07_2017.pdf?1319
[112]
Framroze B. A placebo-controlled, randomized study on the impact of dietary salmon protein hydrolysate supplementation on body mass index in overweight human subjects. J Obes Weight Loss Therapy 2016.
[http://dx.doi.org/10.4172/2165-7904.1000296]
[113]
Crowley D. New 128-day study on collago® show increased energy and anti-inflammatory effects, KS Inc, Editor 2019. Available from: https://ichgcp.net/clinical-trials-registry/NCT03535571
[114]
Framroze B. A comparative study of the impact of dietary calcium sources on serum calcium and bone reformation using an ovariectomized sprague-dawley rat model. J Nutr Food Sci 2014; 5.

© 2022 Bentham Science Publishers | Privacy Policy