Abstract
Background: An increase in resistant gram-positive cocci, especially enterococci, requires an epidemiologic re-assay and its results may affect empirical treatments for these infections.
Objective: In this study, we investigated the microbial epidemiology and resistance pattern of enterococcal bacteremia.
Methods: This study was a cross-sectional study that investigated all cases of positive blood cultures with Enterococcus spp. at a tertiary referral colligates hospital in Tehran in 2018.
Results: Enterococcus spp. was isolated from blood cultures of a total of 73 patients. Most of the patients were male i.e: 42 (57.7%). The mean age of the patients was 58.8 (±18.8) years. Hospital- acquired infection was the most prevalent type of infection involving enterococcal bacteremia (80.8%) compared with community-acquired (6.7%) and the health care-associated one (12.3%). Renal failure and cancer were the most underlying disease in E. faecalis and E. faecium, respectively. Mortality for Vancomycin-resistant enterococci (VRE) was approximately two times more than the sensitive ones. Between the dead/alive groups, the following items were significantly different (P.Value<0.05): Vancomycin resistance for enterococcus isolated, immunodeficiency as an underlying disease, Mechanical ventilation, hospitalization period, and the empiric regimen.
Conclusion: Increased antibiotic-resistant strains, especially Vancomycin-resistant enterococci (VRE), pose a serious threat to the general public, especially hospitalized patients, causing an increase in mortality. Surveillance of microorganisms and antimicrobial resistance is a crucial part of an efficient health care system.
Keywords: Enterococcal bacteremia, Enterococcus faecalis, Enterococcus faecium, resistance, microorganisms, epidemiology.
[http://dx.doi.org/10.2147/AHMT.S180489] [PMID: 30532606]
[http://dx.doi.org/10.1086/491711] [PMID: 16323116]
[http://dx.doi.org/10.1016/j.ajic.2004.10.001] [PMID: 15573054]
[http://dx.doi.org/10.1016/j.bbmt.2008.10.024] [PMID: 19135942]
[http://dx.doi.org/10.1186/s12879-015-1175-6] [PMID: 26471715]
[http://dx.doi.org/10.1093/cid/cix232] [PMID: 28369204]
[http://dx.doi.org/10.1007/s100960000429] [PMID: 11305477]
[http://dx.doi.org/10.1007/s15010-014-0678-1] [PMID: 25143193]
[http://dx.doi.org/10.7860/JCDR/2016/20562.8418] [PMID: 27790430]
[PMID: 14758373]
[http://dx.doi.org/10.1086/649020] [PMID: 19951200]
[http://dx.doi.org/10.4103/0974-777X.93758] [PMID: 22529624]
[http://dx.doi.org/10.1007/s10096-009-0830-5] [PMID: 19916034]
[http://dx.doi.org/10.1016/j.ijid.2016.11.005] [PMID: 27836794]
[http://dx.doi.org/10.1111/1469-0691.12132] [PMID: 23398607]
[PMID: 26244026]
[http://dx.doi.org/10.1128/AAC.06299-11] [PMID: 22354290]
[http://dx.doi.org/10.14744/ejmi.2019.23641]
[PMID: 16008327]
[http://dx.doi.org/10.1016/j.jiac.2017.03.009] [PMID: 28385565]
[http://dx.doi.org/10.1097/CCM.0000000000003264] [PMID: 29957707]
[http://dx.doi.org/10.1086/501795] [PMID: 10968716]
[http://dx.doi.org/10.7326/0003-4819-135-7-200110020-00007] [PMID: 11578151]
[http://dx.doi.org/10.1016/j.jinf.2009.01.013] [PMID: 19233476]