Abstract
RNA helicase A (RHA) is a DExH-box helicase that plays regulatory roles in a variety of cellular processes, including transcription, translation, RNA splicing, editing, transport, and processing, microRNA genesis and maintenance of genomic stability. It is involved in virus replication, oncogenesis, and innate immune response. RHA can unwind nucleic acid duplex by nucleoside triphosphate hydrolysis. The insight into the molecular mechanism of helicase activity is fundamental to understanding the role of RHA in the cell. Herein, we reviewed the current advances on the helicase activity of RHA and its relevance to gene expression, particularly, to the genesis of circular RNA.
Keywords: RNA helicase A, ATPase, helicase activity, unwinding, circRNAs, DExH-box helicase.
Current Protein & Peptide Science
Title:The Current View on the Helicase Activity of RNA Helicase A and Its Role in Gene Expression
Volume: 22 Issue: 1
Author(s): Yuan-Qing Pan and Li Xing*
Affiliation:
- Institute of Biomedical Sciences, Shanxi University, 92 Wucheng Road, Taiyuan 030006, Shanxi province,China
Keywords: RNA helicase A, ATPase, helicase activity, unwinding, circRNAs, DExH-box helicase.
Abstract: RNA helicase A (RHA) is a DExH-box helicase that plays regulatory roles in a variety of cellular processes, including transcription, translation, RNA splicing, editing, transport, and processing, microRNA genesis and maintenance of genomic stability. It is involved in virus replication, oncogenesis, and innate immune response. RHA can unwind nucleic acid duplex by nucleoside triphosphate hydrolysis. The insight into the molecular mechanism of helicase activity is fundamental to understanding the role of RHA in the cell. Herein, we reviewed the current advances on the helicase activity of RHA and its relevance to gene expression, particularly, to the genesis of circular RNA.
Export Options
About this article
Cite this article as:
Pan Yuan-Qing and Xing Li *, The Current View on the Helicase Activity of RNA Helicase A and Its Role in Gene Expression, Current Protein & Peptide Science 2021; 22 (1) . https://dx.doi.org/10.2174/1389203721666201103084122
DOI https://dx.doi.org/10.2174/1389203721666201103084122 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
Call for Papers in Thematic Issues
Advancements in Proteomic and Peptidomic Approaches in Cancer Immunotherapy: Unveiling the Immune Microenvironment
The scope of this thematic issue centers on the integration of proteomic and peptidomic technologies into the field of cancer immunotherapy, with a particular emphasis on exploring the tumor immune microenvironment. This issue aims to gather contributions that illustrate the application of these advanced methodologies in unveiling the complex interplay ...read more
Artificial Intelligence for Protein Research
Protein research, essential for understanding biological processes and creating therapeutics, faces challenges due to the intricate nature of protein structures and functions. Traditional methods are limited in exploring the vast protein sequence space efficiently. Artificial intelligence (AI) and machine learning (ML) offer promising solutions by improving predictions and speeding up ...read more
Biomarkers in Diagnostics and Therapeutics: Advancements in Proteins and Peptides Across Preclinical and Clinical Studies
Biomarkers play a crucial role in the understanding and management of diseases, enabling clinicians and researchers to diagnose conditions earlier, predict disease outcomes, and develop personalized treatment strategies. Proteins and peptides, as key molecular entities, hold substantial promise in revolutionizing biomarker discovery, especially in the context of complex diseases such ...read more
Nutrition and Metabolism in Musculoskeletal Diseases
The musculoskeletal system consists mainly of cartilage, bone, muscles, tendons, connective tissue and ligaments. Balanced metabolism is of vital importance for the homeostasis of the musculoskeletal system. A series of musculoskeletal diseases (for example, sarcopenia, osteoporosis) are resulted from the dysregulated metabolism of the musculoskeletal system. Furthermore, metabolic diseases (such ...read more
Related Journals

- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Exploiting Protein Phosphatase Inhibitors Based on Cantharidin Analogues for Cancer Drug Discovery
Mini-Reviews in Medicinal Chemistry Soluble and Non-Aggregated Phthalocyanines: Synthesis, Mechanistic Aspects and Their Main Building Blocks
Current Organic Synthesis Improving Cancer Therapeutics by Molecular Profiling
Current Drug Metabolism ThermoTRP Channels in Nociceptors: Taking a Lead from Capsaicin Receptor TRPV1
Current Neuropharmacology Meet Our Editorial Board Member
Current Medicinal Chemistry Detection of Fungal Infections Using Radiolabeled Antifungal Agents
Current Drug Targets Lymphatic Targeting of Nanosystems for Anticancer Drug Therapy
Current Pharmaceutical Design Potential Therapeutic Benefits of Dipyridamole in COVID-19 Patients
Current Pharmaceutical Design The Role of Oxidative Stress and Anti-Oxidant Treatment in Platinum- Induced Peripheral Neurotoxicity
Current Cancer Drug Targets Development of Metal-Based Drugs and Application in Clinical Treatment
The Natural Products Journal The Centrosome: A Target for Cancer Therapy
Current Cancer Drug Targets Chemokine Like Receptor-1 (CMKLR-1) Receptor: A Potential Therapeutic Target in Management of Chemerin Induced Type 2 Diabetes Mellitus and Cancer
Current Pharmaceutical Design Prediction of Disease-Related Genes Based on Hybrid Features
Current Proteomics Role of Vitamins in Human Health and Nutrition: Sources and Morbidity
Current Nutrition & Food Science Genetic Engineering - A New Era for Cancer Immunotherapy?
Current Cancer Therapy Reviews Drug Repurposing in Oncology: Current Evidence and Future Direction
Current Medicinal Chemistry Adhesion Molecules in Lung Cancer: Implications in the Pathogenesis and Management
Current Pharmaceutical Design Cancer Stem Cells and Combination Therapies to Eradicate Them
Current Pharmaceutical Design Dendritic Cells and the Promise of Therapeutic Vaccines for Human Immunodeficiency Virus (HIV)-1
Current HIV Research Prostate Cancer: Biology, Incidence, Detection Methods, Treatment Methods, and Vaccines
Current Topics in Medicinal Chemistry