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Current Protein & Peptide Science


ISSN (Print): 1389-2037
ISSN (Online): 1875-5550

Review Article

The Current View on the Helicase Activity of RNA Helicase A and Its Role in Gene Expression

Author(s): Yuan-Qing Pan and Li Xing*

Volume 22, Issue 1, 2021

Published on: 03 November, 2020

Page: [29 - 40] Pages: 12

DOI: 10.2174/1389203721666201103084122

Price: $65


RNA helicase A (RHA) is a DExH-box helicase that plays regulatory roles in a variety of cellular processes, including transcription, translation, RNA splicing, editing, transport, and processing, microRNA genesis and maintenance of genomic stability. It is involved in virus replication, oncogenesis, and innate immune response. RHA can unwind nucleic acid duplex by nucleoside triphosphate hydrolysis. The insight into the molecular mechanism of helicase activity is fundamental to understanding the role of RHA in the cell. Herein, we reviewed the current advances on the helicase activity of RHA and its relevance to gene expression, particularly, to the genesis of circular RNA.

Keywords: RNA helicase A, ATPase, helicase activity, unwinding, circRNAs, DExH-box helicase.

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