Present and Future Treatment of Mycobacteria

J.   C.   Rodriguez; I.      Escribano; R.   A.   Gomez; E.   Garcia   Pachon; A.      Navarro; G.      Royo

Abstract

To review the treatments currently used to treat mycobacteria (latent tuberculosis, clinical tuberculosis, infections due to mycobacteria), focussing on : Doses administered and duration of treatment Levels reached in different body tissues in relation to the chemical characteristics of the drugs The relation between these data and the microbiological parameters of each microorganism To review the above parameters for the new groups of drugs being investigated for treatment of the three pathologies. a. fluorquinolones b. macrolides c. rifampicins d. oxazolidinones e. tetracyclines f.- other drugs undergoing investigation

Keywords: Mycobacterium tuberculosis, rifampicin resistance, fluoroquinolones, Mycobacterium avium, M-DCMG conjugate