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Current Pharmaceutical Biotechnology


ISSN (Print): 1389-2010
ISSN (Online): 1873-4316

Review Article

Recent Advances in Clinical Utility of Probiotics in Gastrointestinal Tract Disorders

Author(s): Prativa Biswasroy, Deepak Pradhan, Dipak K. Sahu, Amita Sahu, Goutam Ghosh and Goutam Rath*

Volume 22, Issue 12, 2021

Published on: 29 October, 2020

Page: [1559 - 1573] Pages: 15

DOI: 10.2174/1389201021666201029154239

Price: $65


Clinically, probiotics have a significant role in nutrition, immune function, and maintenance of gut homeostasis. Unfortunately, the widespread use of antibiotics disrupts the symbiotic balance of gut microbiota, leading to the development of several gastrointestinal disorders. A recent study suggesting a combination of appropriate probiotics and prebiotics through its ability to fix dysbiosis issues has emerged as a potential alternative to treat various pathological conditions of the Gastrointestinal Tract (GIT). Evidenced-based clinical research suggests that probiotic's effectiveness depends on several factors including strain, dose, host immune system, underlying pathology, and duration of therapy. Moreover, the microflora enriched medium reinforces the host defense against chemical and microbial challenges. However, the limited information available to understand the molecular basis by which probiotic maintains the gut homeostasis. The objective of this review to emphasize recent clinical outcomes and possible mechanisms involved in probiotic action to combat the GIT disorders.

Keywords: Antibiotics, gut flora, prebiotic, clinical indications, gastrointestinal tract disease, gut-brain axis.

Graphical Abstract

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