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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607


Perspectives for the Use of N-acetylcysteine as a Candidate Drug to Treat COVID-19

Author(s): Pan Luo, Yi Liu, Dong Liu* and Juan Li*

Volume 21, Issue 3, 2021

Published on: 27 October, 2020

Page: [268 - 272] Pages: 5

DOI: 10.2174/1389557520666201027160833


Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndromerelated coronavirus-2 (SARS-CoV-2), has become an ongoing pandemic worldwide. However, there are no vaccines or antiviral drugs with proven clinical efficacy. Therefore, a remedial measure is urgently needed to combat the devastating COVID-19. The pharmacological activities of Nacetylcysteine (NAC) and its potential functions in inhibiting the progression of COVID-19 make it a promising therapeutic agent for the infection. In this mini-review, we discussed the therapeutic potential of NAC in COVID-19 from the perspective of its multisite pharmacological actions.

Keywords: COVID-19, SARS-COV-2, N-acetylcysteine, oxidative stress, inflammation, thrombosis, nitric oxide, mental disorders.

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