摘要
非酒精性脂肪性肝病是一种慢性代谢紊乱,是西方文明中慢性肝病最常见的病因,也是肝硬化的主要病因之一,对最晚期全因死亡率有显著影响。它的特点是在没有明显的乙醇消耗、病毒感染或其他肝病的特定原因的情况下,肝脏脂肪堆积。肝脏组织中脂肪的积累是高脂肪饮食的过度消耗和脂肪生成的增加和脂肪处理的减少之间的不平衡的结果。预防脂肪肝疾病和肝硬化进展的新型饮食和药物疗法是一个实际的研究领域,但仍然知之甚少。从这一角度,本综述旨在总结和阐明转录因子NFκB在非酒精性脂肪肝及其进展中的作用。通过以往广泛的研究,我们已经清楚地发现,非酒精性脂肪肝的发病机制涉及到多个信号通路:代谢失调(如游离脂肪酸增加、脂肪因子改变、胰岛素抵抗)、氧化应激和炎症共同构成“恶性循环”。其中,NFκB信号是炎症反应和疾病的主要因素,与代谢、氧化、免疫和炎症系统之间的重要分子联系。
关键词: 非酒精性脂肪性肝病,核因子kappa b,非酒精性脂肪性肝炎,肝脂肪变性炎症,氧化应激
Current Molecular Medicine
Title:Critical Role of NFκB in the Pathogenesis of Non-alcoholic Fatty Liver Disease: A Widespread Key Regulator
Volume: 21 Issue: 6
关键词: 非酒精性脂肪性肝病,核因子kappa b,非酒精性脂肪性肝炎,肝脂肪变性炎症,氧化应激
摘要: Non-alcoholic fatty liver disease is a chronic metabolic disorder representing the most common cause of chronic liver disease in western civilization and one of the main causes of cirrhosis with a significant impact on all-cause mortality in the most advanced phases. It is characterized by hepatic fat accumulation in the absence of significant ethanol consumption, virus infection or other specific causes of liver disease. Accumulation of fat in liver tissue occurs as a consequence of the imbalance between overconsumption of high-fat diet and increased de novo lipogenesis and decreased lipid disposal. Novel dietary and pharmacological therapies for the prevention of fatty liver disease and the progression to cirrhosis are an actual field of study but still poorly understood. In this perspective, the current review aims to summarise and clarify the transcription factor NFκB effects, which may exert among non-alcoholic fatty liver diseases and their progression. Through extensive previous research, it has become clear that several signaling pathways are involved: metabolic dysregulation (such as free fatty acids increase, adipokine alteration, insulin resistance), oxidative stress and inflammation contribute together in a “vicious circle” to the pathogenesis of non-alcoholic fatty liver diseases. Within this, NFκB signaling is a primary factor in inflammatory reactions and diseases, with important molecular connections between metabolic, oxidative, immune and inflammation systems.
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Cite this article as:
Critical Role of NFκB in the Pathogenesis of Non-alcoholic Fatty Liver Disease: A Widespread Key Regulator, Current Molecular Medicine 2021; 21 (6) . https://dx.doi.org/10.2174/1566524020666201026162343
DOI https://dx.doi.org/10.2174/1566524020666201026162343 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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